Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 90633..91168 Replicon plasmid pESA134_1
Accession NZ_CP070285
Organism Escherichia albertii strain Sample 169

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag JRC46_RS23825 Protein ID WP_001270421.1
Coordinates 90633..90920 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag JRC46_RS23830 Protein ID WP_204620294.1
Coordinates 90917..91168 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JRC46_RS23780 (JRC46_23780) 85655..85951 + 297 Protein_96 transposase -
JRC46_RS25330 86782..87432 - 651 WP_244259620.1 RIO1 family regulatory kinase/ATPase -
JRC46_RS23790 (JRC46_23790) 87601..87747 - 147 Protein_98 IS3 family transposase -
JRC46_RS25335 88068..88340 - 273 Protein_99 secretion protein EspO -
JRC46_RS23795 (JRC46_23795) 88556..88774 - 219 Protein_100 IS200/IS605 family transposase -
JRC46_RS23800 (JRC46_23800) 88929..89306 + 378 WP_204678055.1 hypothetical protein -
JRC46_RS23805 (JRC46_23805) 89548..89869 - 322 Protein_102 epoxyqueuosine reductase QueH -
JRC46_RS23810 (JRC46_23810) 89942..90073 + 132 Protein_103 serine/threonine protein kinase -
JRC46_RS23815 (JRC46_23815) 90180..90512 + 333 Protein_104 tyrosine-type recombinase/integrase -
JRC46_RS23820 (JRC46_23820) 90506..90631 - 126 Protein_105 IS3 family transposase -
JRC46_RS23825 (JRC46_23825) 90633..90920 - 288 WP_001270421.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JRC46_RS23830 (JRC46_23830) 90917..91168 - 252 WP_204620294.1 antitoxin Antitoxin
JRC46_RS23835 (JRC46_23835) 91342..91554 - 213 WP_204620323.1 hypothetical protein -
JRC46_RS23840 (JRC46_23840) 91928..93133 + 1206 WP_000817642.1 AAA family ATPase -
JRC46_RS23845 (JRC46_23845) 93130..94092 + 963 WP_147697683.1 ParB family protein -
JRC46_RS23850 (JRC46_23850) 94233..95429 - 1197 Protein_111 translesion error-prone DNA polymerase V subunit UmuC -
JRC46_RS23855 (JRC46_23855) 95352..95768 + 417 Protein_112 hypothetical protein -
JRC46_RS23860 (JRC46_23860) 95772..96077 + 306 WP_204620293.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - stcE / exeE / exeG 1..120691 120691


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11244.27 Da        Isoelectric Point: 10.4703

>T193666 WP_001270421.1 NZ_CP070285:c90920-90633 [Escherichia albertii]
MRYQVKFREDALKEWQKLDKTIQQQFAKKLKKCCDNPHIPSAKLRGIKDCYKIKLRASGFRLVYQVIDEQLIIAVVAVGK
RERSDVYNLASERMR

Download         Length: 288 bp

>T193666 NZ_CP093068:c4307386-4307099 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAATGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9182.46 Da        Isoelectric Point: 4.2108

>AT193666 WP_204620294.1 NZ_CP070285:c91168-90917 [Escherichia albertii]
MPNIILSDTSASVSELKKNPMATVSAGDGFPVAILNRNQTAFYCVPAELYEKMLDALDDQELVKLVAERSNQPLHDVDLD
KYL

Download         Length: 252 bp

>AT193666 NZ_CP093068:c4307112-4306810 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGACGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References