Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3431073..3431691 Replicon chromosome
Accession NZ_CP070284
Organism Escherichia albertii strain Sample 169

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag JRC46_RS16900 Protein ID WP_001280991.1
Coordinates 3431473..3431691 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B1EKM5
Locus tag JRC46_RS16895 Protein ID WP_000344798.1
Coordinates 3431073..3431447 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JRC46_RS16885 (3426153) 3426153..3427346 + 1194 WP_010334435.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JRC46_RS16890 (3427369) 3427369..3430518 + 3150 WP_204677663.1 multidrug efflux RND transporter permease subunit AcrB -
JRC46_RS16895 (3431073) 3431073..3431447 + 375 WP_000344798.1 Hha toxicity modulator TomB Antitoxin
JRC46_RS16900 (3431473) 3431473..3431691 + 219 WP_001280991.1 HHA domain-containing protein Toxin
JRC46_RS16905 (3431868) 3431868..3432425 + 558 WP_204619451.1 maltose O-acetyltransferase -
JRC46_RS16910 (3432532) 3432532..3433002 + 471 WP_059224581.1 YlaC family protein -
JRC46_RS16915 (3433166) 3433166..3434716 + 1551 WP_001260378.1 EAL domain-containing protein -
JRC46_RS16920 (3434754) 3434754..3435107 - 354 WP_000878151.1 DUF1428 family protein -
JRC46_RS16930 (3435488) 3435488..3435799 + 312 WP_000409915.1 MGMT family protein -
JRC46_RS16935 (3435829) 3435829..3436401 - 573 WP_204619453.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T193655 WP_001280991.1 NZ_CP070284:3431473-3431691 [Escherichia albertii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T193655 NZ_CP093068:1107954-1108289 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14499.35 Da        Isoelectric Point: 4.8989

>AT193655 WP_000344798.1 NZ_CP070284:3431073-3431447 [Escherichia albertii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKANPASLSC

Download         Length: 375 bp

>AT193655 NZ_CP093068:1107706-1107954 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A2T3RX90

References