Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 145792..146317 Replicon plasmid pESA135_2
Accession NZ_CP070283
Organism Escherichia albertii strain Sample 170

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag JRC42_RS24795 Protein ID WP_204678074.1
Coordinates 146012..146317 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag JRC42_RS24790 Protein ID WP_204678073.1
Coordinates 145792..146010 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JRC42_RS24765 (140965) 140965..142086 - 1122 WP_208629374.1 hypothetical protein -
JRC42_RS24770 (142560) 142560..144149 - 1590 WP_204619574.1 IS66 family transposase -
JRC42_RS24775 (144169) 144169..144516 - 348 WP_204619037.1 IS66 family insertion sequence element accessory protein TnpB -
JRC42_RS24780 (144513) 144513..144932 - 420 WP_204619039.1 transposase -
JRC42_RS24785 (145018) 145018..145242 - 225 Protein_154 type II toxin-antitoxin system VapB family antitoxin -
JRC42_RS24790 (145792) 145792..146010 + 219 WP_204678073.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
JRC42_RS24795 (146012) 146012..146317 + 306 WP_204678074.1 type II toxin-antitoxin system toxin CcdB Toxin
JRC42_RS24800 (146318) 146318..147115 + 798 Protein_157 site-specific integrase -
JRC42_RS24805 (147372) 147372..147572 + 201 Protein_158 site-specific integrase -
JRC42_RS24810 (147618) 147618..148361 - 744 Protein_159 IS3 family transposase -
JRC42_RS24815 (148366) 148366..148545 - 180 Protein_160 IS66 family insertion sequence element accessory protein TnpB -
JRC42_RS24820 (148532) 148532..148843 - 312 WP_204620362.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - espC / espC 1..176494 176494
- inside IScluster/Tn - - 132380..148370 15990


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11684.50 Da        Isoelectric Point: 5.8430

>T193633 WP_204678074.1 NZ_CP070283:146012-146317 [Escherichia albertii]
MQFKVYTYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVLVGDESWRMMTTDMSSVPVSVIGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

>T193633 NZ_CP093043:c1795920-1795633 [Bartonella krasnovii]
ATGCTTCCGGTTGTTTGGTTGTCTTCGGCTCGCGATGATTTGCGTCAGATTTTAACTTACATTGCTCGCGAAAATCCATC
CGCTGCACGCCGAATGAAAAGGTTTTTGGAAACATCTGTACTGCCATTGGCTGAACATCCATATCTGTACAGACAGAGTG
AGAGGATATTAGGGTTACGGGAAATTATAGCACATCCAAATTACCTTATATTGTATCGAGTAGCTGCAAATCAGATCGAA
ATTGTAGCTGTCGTACATGCCCGACGTGAATTCCCTACCTCTCTTTAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8399.41 Da        Isoelectric Point: 5.0506

>AT193633 WP_204678073.1 NZ_CP070283:145792-146010 [Escherichia albertii]
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWKAENQEGMVEVARFIEMNGSFADENRNW

Download         Length: 219 bp

>AT193633 NZ_CP093043:c1796108-1795920 [Bartonella krasnovii]
ATGAAAAACACCCTTTCTCCGTTCATTTCAGAGTTCGAAACTATTGAACAGGAAAGCAGCCACACGGCGTGGTTGCGCGA
TAAGGTCGCGATAAGTCTTGCAAACCTATCTCCTCCTATTCCGCATGATGAGGTCATGGCTGAAATGGACGTTATAATCA
GTCAGCTTGAAAATGAACAGAAAAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References