Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3431074..3431692 Replicon chromosome
Accession NZ_CP070281
Organism Escherichia albertii strain Sample 170

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag JRC42_RS16900 Protein ID WP_001280991.1
Coordinates 3431474..3431692 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B1EKM5
Locus tag JRC42_RS16895 Protein ID WP_000344798.1
Coordinates 3431074..3431448 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JRC42_RS16885 (3426154) 3426154..3427347 + 1194 WP_010334435.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JRC42_RS16890 (3427370) 3427370..3430519 + 3150 WP_204677663.1 multidrug efflux RND transporter permease subunit AcrB -
JRC42_RS16895 (3431074) 3431074..3431448 + 375 WP_000344798.1 Hha toxicity modulator TomB Antitoxin
JRC42_RS16900 (3431474) 3431474..3431692 + 219 WP_001280991.1 HHA domain-containing protein Toxin
JRC42_RS16905 (3431869) 3431869..3432426 + 558 WP_204619451.1 maltose O-acetyltransferase -
JRC42_RS16910 (3432533) 3432533..3433003 + 471 WP_059224581.1 YlaC family protein -
JRC42_RS16915 (3433167) 3433167..3434717 + 1551 WP_001260378.1 EAL domain-containing protein -
JRC42_RS16920 (3434755) 3434755..3435108 - 354 WP_000878151.1 DUF1428 family protein -
JRC42_RS16930 (3435489) 3435489..3435800 + 312 WP_000409915.1 MGMT family protein -
JRC42_RS16935 (3435830) 3435830..3436402 - 573 WP_204619453.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T193619 WP_001280991.1 NZ_CP070281:3431474-3431692 [Escherichia albertii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T193619 NZ_CP093040:c1690498-1690211 [Bartonella krasnovii]
ATGCTTCCGGTTGTTTGGTTGTCTTCGGCTCGCGATGATTTGCGTCAGATTTTAACTTACATTGCTCGTGAAAATCCATC
CGCTGCACGCCGAATGAAAAGGTTTTTGGAAACATCTGTACTGCCATTGGCTGAACATCCATATCTGTACAGACAGAGTG
AGAGGATATTAGGGTTACGGGAAATTATAGCACATCCAAATTACCTTATATTGTATCGAGTAGCTGCAAATCAGATCGAA
ATTGTAGCTGTCGTACATGCCCGACGTGAATTCCCTACCTCTCTTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14499.35 Da        Isoelectric Point: 4.8989

>AT193619 WP_000344798.1 NZ_CP070281:3431074-3431448 [Escherichia albertii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKANPASLSC

Download         Length: 375 bp

>AT193619 NZ_CP093040:c1690686-1690498 [Bartonella krasnovii]
ATGAAAAACACCCTTTCTCCGTTCATTTCAGAGTTCGAAACTATTGAACAGGAAAGCAGCCACACGGCGTGGTTGCGCGA
TAAGGTCGCGATAAGTCTTGCAAACCTATCTCCTCCTATTCCGCATGATGAGGTCATGGCTGAAATGGACGTTATAATCA
GTCAGCTTGAAAATGAACAGAAAAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A2T3RX90

References