Detailed information of TA system TA193617

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 2353810..2354414
• Replicon: chromosome
• Accession: NZ_CP070281
• Organism: Escherichia albertii strain Sample 170

Toxin (Protein)

• Gene name: doc
• Uniprot ID: B1EM00
• Locus tag: JRC42_RS11600
• Protein ID: WP_000638401.1
• Coordinates: 2354028..2354414 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: -
• Locus tag: JRC42_RS11595
• Protein ID: WP_204620194.1
• Coordinates: 2353810..2354031 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JRC42_RS11575 (2349957)	2349957..2350871	+	915	WP_024164792.1	bestrophin family protein	-
JRC42_RS11580 (2350875)	2350875..2351633	-	759	WP_054410601.1	trans-aconitate 2-methyltransferase	-
JRC42_RS25090 (2351954)	2351954..2352448	-	495	WP_244259603.1	hypothetical protein	-
JRC42_RS11590 (2352663)	2352663..2353470	-	808	Protein_2297	helix-turn-helix domain-containing protein	-
JRC42_RS11595 (2353810)	2353810..2354031	+	222	WP_204620194.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
JRC42_RS11600 (2354028)	2354028..2354414	+	387	WP_000638401.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
JRC42_RS25095 (2354494)	2354494..2355561	-	1068	WP_279632101.1	autotransporter outer membrane beta-barrel domain-containing protein	-
JRC42_RS25495 (2355558)	2355558..2356043	-	486	WP_279632102.1	autotransporter outer membrane beta-barrel domain-containing protein	-
JRC42_RS11605 (2356040)	2356040..2359264	-	3225	WP_244259604.1	ESPR-type extended signal peptide-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2319882..2362853	42971
	-	flank	IS/Tn	-	-	2352663..2353049	386

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (3-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-55)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14505.49 Da
• Isoelectric Point: 8.0833

>T193617 WP_000638401.1 NZ_CP070281:2354028-2354414 [Escherichia albertii]
MIWVSAQEVIAFHDRILQRFPGVAGLTDPGRAQALIYRVQNRVHYEGVTDLFELAATYWVAIARGHIFHDGNKRTAFFVT
MTFLWRNGIRIRDVDNSLENLTVEAATGEKTVGQLARCLRERVDSSGN

Nucleotide

• Length: 387 bp

>T193617 NZ_CP093040:c933632-933300 [Bartonella krasnovii]
ATGAAGCGGGGAGAGATTTGGCTTGTATCTCTTGACCCATCTTCGGGTTATGAACAAAAAGGAACGCGTCCTGTACTGAT
TGTATCACCAGAAGCGTTTAATCGTGTAACGAAAACACCTATTGTCTTGCCTATTACAAGCGGGGGGAATTTTGCTAGAA
CAGCAGGTTTTGCTGTCTCATTAATGGGAGTAGGATTGCATACAACAGGCGTGATACGTTGTGACCAGCCACGTGCTCTT
GATATTGGAGCGCGTCAGGGTAAAAAAATGGAAACAGTTCCCCCTATGATAATGAACGAAGTTCTTGCTAAGCTAGCAAC
ATTTCTCACGTAG

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8066.97 Da
• Isoelectric Point: 4.9731

>AT193617 WP_204620194.1 NZ_CP070281:2353810-2354031 [Escherichia albertii]
MQTYTSTQARANIATVLDTALNGEPVEITRRDGSSAVLISKAAFEAYQNAKLDAEFNAIMQRHEHTIEALTDR

Nucleotide

• Length: 222 bp

>AT193617 NZ_CP093040:c933889-933632 [Bartonella krasnovii]
ATGTATACAACAAAATTACGTAAAGTTGGAGGGTCAGTGATGCTTTCTATACCACCTGCCTTGCTTGATGTTCTCCATCT
TACTGAAAACACACAAGTGGGCTTGGCTGTTGATAATGGACAATTGATTGTGAAGCCACAAACATTTCCAAGTTACACTC
TTGATGAATTATTAGCCCAATGTAATCCTTCAGATGATTTTGCGGATGAGGATATAGAGTGGTTTGATGCTCAACCTGTT
GGTAGCGAGCTTTTGTAA

Structures

Toxin

• AlphaFold DB: A0A3T5VDW2