Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 855281..855932 Replicon chromosome
Accession NZ_CP070281
Organism Escherichia albertii strain Sample 170

Toxin (Protein)


Gene name cptA Uniprot ID B1EG01
Locus tag JRC42_RS04140 Protein ID WP_000244763.1
Coordinates 855528..855932 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag JRC42_RS04135 Protein ID WP_000354046.1
Coordinates 855281..855547 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JRC42_RS04110 (850992) 850992..852425 - 1434 WP_204619935.1 6-phospho-beta-glucosidase -
JRC42_RS04115 (852470) 852470..852781 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
JRC42_RS04120 (852949) 852949..853608 + 660 WP_000250281.1 hemolysin III family protein -
JRC42_RS04125 (854049) 854049..855029 - 981 WP_000886056.1 tRNA-modifying protein YgfZ -
JRC42_RS04130 (855061) 855061..855291 + 231 WP_000181267.1 hypothetical protein -
JRC42_RS04135 (855281) 855281..855547 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
JRC42_RS04140 (855528) 855528..855932 + 405 WP_000244763.1 protein YgfX Toxin
JRC42_RS04145 (855971) 855971..856492 - 522 WP_125060507.1 flavodoxin FldB -
JRC42_RS04150 (856604) 856604..857500 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
JRC42_RS04155 (857525) 857525..858235 + 711 WP_000748105.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JRC42_RS04160 (858241) 858241..859974 + 1734 WP_204619936.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15888.81 Da        Isoelectric Point: 11.1732

>T193606 WP_000244763.1 NZ_CP070281:855528-855932 [Escherichia albertii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAAILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVRAPWMIKTGMMLRLLSDSGKRQHLWLAADSMDEAEWRDLRRILLQQEIQ

Download         Length: 405 bp

>T193606 NZ_CP093038:926551-926883 [Bartonella krasnovii]
ATGAAGCGGGGAGAGATTTGGCTTGTATCTCTTGACCCATCTTCGGGTTATGAACAAAAAGGAACGCGTCCTGTACTGAT
TGTATCACCAGAAGCGTTTAATCGTGTAACGAAAACACCTATTGTCTTGCCTATTACAAGCGGGGGGAATTTTGCTAGAA
CAGCAGGTTTTGCTGTCTCATTAATGGGAGTAGGATTGCATACAACAGGCGTGATACGTTGTGACCAGCCACGTGCTCTT
GATATTGGAGCGCGTCAGGGTAAAAAAATGGAAACAGTTCCCCCTATGATAATGAACGAAGTTCTTGCTAAGCTAGCAAC
ATTTCTCACGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT193606 WP_000354046.1 NZ_CP070281:855281-855547 [Escherichia albertii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT193606 NZ_CP093038:926294-926551 [Bartonella krasnovii]
ATGTATACAACAAAATTACGTAAAGTTGGAGGGTCAGTGATGCTTTCTATACCACCTGTCTTGCTTGATGTTCTCCATCT
TACTGAAAACACACAAGTGGGCTTGGCTGTTGATAATGGACAATTGATTGTGAAGCCACAAACATTTCCAAGTTACACTC
TTGATGAATTATTAGCCCAATGTAATCCTTCAGTTGATTTTGCGGATGAGGATATAGAGTGGTTTGATGCTCAACCTGTT
GGTAGCGAGCTTTTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6P9B3

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References