Detailed information of TA system TA193604

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ataRT/DUF1778(antitoxin)
• Location: 278868..279668
• Replicon: chromosome
• Accession: NZ_CP070281
• Organism: Escherichia albertii strain Sample 170

Toxin (Protein)

• Gene name: ataT
• Uniprot ID: B1EHN9
• Locus tag: JRC42_RS01285
• Protein ID: WP_000342453.1
• Coordinates: 279141..279668 (+)
• Length: 176 a.a.

Antitoxin (Protein)

• Gene name: ataR
• Uniprot ID: B1EHP0
• Locus tag: JRC42_RS01280
• Protein ID: WP_001277106.1
• Coordinates: 278868..279134 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JRC42_RS01255 (274589)	274589..275443	-	855	WP_000370583.1	PTS system mannose/fructose/sorbose family transporter subunit IID	-
JRC42_RS01260 (275436)	275436..276182	-	747	WP_000151888.1	PTS sugar transporter subunit IIC	-
JRC42_RS01265 (276199)	276199..276684	-	486	WP_000029259.1	PTS sugar transporter subunit IIB	-
JRC42_RS01270 (276691)	276691..277092	-	402	WP_001071334.1	PTS sugar transporter subunit IIA	-
JRC42_RS01275 (277615)	277615..278718	+	1104	WP_204619850.1	branched-chain amino acid ABC transporter substrate-binding protein	-
JRC42_RS01280 (278868)	278868..279134	+	267	WP_001277106.1	type II toxin-antitoxin system antitoxin AtaR	Antitoxin
JRC42_RS01285 (279141)	279141..279668	+	528	WP_000342453.1	type II toxin-antitoxin system toxin acetyltransferase AtaT	Toxin
JRC42_RS01290 (279665)	279665..280048	-	384	WP_000778774.1	aspartate 1-decarboxylase autocleavage activator PanM	-
JRC42_RS01295 (280472)	280472..281581	+	1110	WP_000827693.1	high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK	-
JRC42_RS01300 (281629)	281629..282555	+	927	WP_001295111.1	high-affinity branched-chain amino acid ABC transporter permease LivH	-
JRC42_RS01305 (282552)	282552..283829	+	1278	WP_059225128.1	branched chain amino acid ABC transporter permease LivM	-
JRC42_RS01310 (283826)	283826..284593	+	768	WP_059218997.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (88-150)

Antitoxin

• Vibrio phage ICP1, Orf50 (8-86)

Sequences

Toxin

Protein

• Length: 176 a.a.
• Molecular weight: 19676.58 Da
• Isoelectric Point: 6.9585

>T193604 WP_000342453.1 NZ_CP070281:279141-279668 [Escherichia albertii]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTQSD

Nucleotide

• Length: 528 bp

>T193604 NZ_CP093037:c916672-916364 [Bartonella krasnovii]
ATGATACTCATTCATAAAACAATAGAATTTGATACTTGGCTTAAGAAACTTAAAGATAAAAGCGTTAAGGCTATTATTCT
TCAACGTGTTGTACGCTTAAAACAAGGACTTTTCGGTGATGTTAAATTCTTTCATGGCATAGGGGAATTACGTATCCACT
ATGGTGCTGGTTACAGAATTTATTTTACCCAAAAAGGCTCTGATTTTATCCTTTTGTTATGCGGTGGAGATAAATCAACG
CAGCAAAGAGATATTGAACAAGCGTTAAAATTAAAAGAGGAGTACAGTGATGAAAATAACCCCATTTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9942.37 Da
• Isoelectric Point: 10.0863

>AT193604 WP_001277106.1 NZ_CP070281:278868-279134 [Escherichia albertii]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILNEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Nucleotide

• Length: 267 bp

>AT193604 NZ_CP093037:c916383-916099 [Bartonella krasnovii]
ATGAAAATAACCCCATTTAAACCAGAAGAATATCTTAAAGACATTGAGTCACAGAAAATTTTTCTCAATGAAGCCCTTAA
AACCGGTGATGCCGCCCACATTGCCGATGCTCTTGGTATCGTTGCTCGTGCCCAAAATATGAGTGCCTTAGCAAAAGAAA
CCAATCGCGAACGCAGTGGATTATACCGTTCCTTAAGTAAAACGGGTGACCCAAAGCTTTCTACCTTAGTCGCTGTATTA
TCTGCCCTTAATTTACAACTCTCTGTACAATCTTCTACTTCATAA

Structures

Antitoxin

• AlphaFold DB: A0A7Z8E004