Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 3586883..3587586 Replicon chromosome
Accession NZ_CP070232
Organism Escherichia coli strain 10R

Toxin (Protein)


Gene name ypjF Uniprot ID A0A8H9SVB9
Locus tag JTF63_RS17205 Protein ID WP_072003801.1
Coordinates 3586883..3587248 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A8H9SW74
Locus tag JTF63_RS17210 Protein ID WP_032250315.1
Coordinates 3587269..3587586 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JTF63_RS17185 3582051..3583007 + 957 WP_000643333.1 aldehyde oxidoreductase FAD-binding subunit PaoB -
JTF63_RS17190 3583004..3585202 + 2199 WP_000667026.1 aldehyde oxidoreductase molybdenum-binding subunit PaoC -
JTF63_RS17195 3585212..3586168 + 957 WP_000121359.1 molybdenum cofactor insertion chaperone PaoD -
JTF63_RS17200 3586219..3586557 + 339 Protein_3361 LysR family transcriptional regulator -
JTF63_RS17205 3586883..3587248 - 366 WP_072003801.1 TA system toxin CbtA family protein Toxin
JTF63_RS17210 3587269..3587586 - 318 WP_032250315.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JTF63_RS17215 3587683..3587826 - 144 WP_072003800.1 DUF987 family protein -
JTF63_RS17220 3587835..3588317 - 483 WP_032250314.1 DNA repair protein RadC -
JTF63_RS17225 3588326..3588784 - 459 WP_204689247.1 antirestriction protein -
JTF63_RS17230 3588798..3589045 - 248 Protein_3367 DUF905 family protein -
JTF63_RS17235 3589385..3591049 - 1665 WP_032250311.1 ATP-dependent helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fdeC / ykgK/ecpR / yagZ/ecpA / yagY/ecpB / yagX/ecpC / yagW/ecpD / yagV/ecpE 3560388..3612407 52019


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(5-103)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13583.80 Da        Isoelectric Point: 8.8806

>T193593 WP_072003801.1 NZ_CP070232:c3587248-3586883 [Escherichia coli]
MKTLPATISRAAKPCLSPVAVWQMLLTRLLKKHYGLTLNDTPFCDQTVIQEHIDAGITLANAVNFLVEKHELVRIDRTGF
TSQEQAPYLTVTDILHARRACGLMNSCSYREVSNIVLSRSR

Download         Length: 366 bp

>T193593 NZ_CP093035:714406-714738 [Bartonella krasnovii]
ATGAAGCGGGGAGAGATTTGGCTTGTATCTCTTGACCCATCTTCGGGTTATGAACAAAAAGGAACGCGTCCTGTACTGAT
TGTATCACCAGAAGCGTTTAATCGTGTAACGAAAACACCTATTGTCTTGCCTATTACAAGCGGGGGGAATTTTGCTAGAA
CAGCAGGTTTTGCTGTCTCATTAATGGGAGTAGGATTGCATACAACAGGCGTGATACGTTGTGACCAGCCACGTGCTCTT
GATATTGGAGCGCGTCAGGGTAAAAAAATGGAAACAGTTCCCCCTATGATAATGAACGAAGTTCTTGCTAAGCTAGCAAC
ATTTCTCACGTAG

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11873.59 Da        Isoelectric Point: 6.8407

>AT193593 WP_032250315.1 NZ_CP070232:c3587586-3587269 [Escherichia coli]
MSNITWGLQRDITPRLGARLVQEGNRLHYLADRASITGKFSDAECLKLDVAFPQFISQMESMLTTGEMNPRHAHCVILYH
NGFTCEADTFGSCGYVYIAIYPIQR

Download         Length: 318 bp

>AT193593 NZ_CP093035:714149-714406 [Bartonella krasnovii]
ATGTATACAACAAAATTACGTAAAGTTGGAGGGTCAGTGATGCTTTCTATACCACCTGTCTTGCTTGATGTTCTCCATCT
TACTGAAAACACACAAGTGGGCTTGGCTGTTGATAATGGACAATTGATTGTGAAGCCACAAACATTTCCAAGTTACACTC
TTGATGAATTATTAGCCCAATGTAATCCTTCAGTTGATTTTGCGGATGAGGATATAGAGTGGTTTGATGCTCAACCTGTT
GGTAGCGAGCTTTTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References