193592

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3403546..3404164 Replicon chromosome
Accession NZ_CP070232
Organism Escherichia coli strain 10R

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag JTF63_RS16345 Protein ID WP_001291435.1
Coordinates 3403946..3404164 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag JTF63_RS16340 Protein ID WP_000344800.1
Coordinates 3403546..3403920 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JTF63_RS16330 3398635..3399828 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JTF63_RS16335 3399851..3403000 + 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
JTF63_RS16340 3403546..3403920 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
JTF63_RS16345 3403946..3404164 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
JTF63_RS16350 3404336..3404887 + 552 WP_000102564.1 maltose O-acetyltransferase -
JTF63_RS16355 3405003..3405473 + 471 WP_000136192.1 YlaC family protein -
JTF63_RS16360 3405637..3407187 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
JTF63_RS16365 3407229..3407582 - 354 WP_000878140.1 DUF1428 domain-containing protein -
JTF63_RS16375 3407961..3408272 + 312 WP_000409911.1 MGMT family protein -
JTF63_RS16380 3408303..3408875 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T193592 WP_001291435.1 NZ_CP070232:3403946-3404164 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T193592 NZ_CP093034:c1669183-1668896 [Bartonella krasnovii]
ATGCTTCCGGTTGTTTGGTTGTCTTCGGCTCGCGATGATTTGCGTCAGATTTTAACTTACATTGCTCGCGAAAATCCATC
CGCTGCACGCCGAATGAAAAGGTTTTTGGAAACATCTGTACTGCCATTGGCTGAACATCCATATCTGTACAGACAGAGTG
AGAGGATATTAGGGTTACGGGAAATTATAGCACATCCAAATTACCTTATATTGTATCGAGTAGCTGCAAATCAGATCGAA
ATTGTAGCTGTCGTACATGCCCGACGTGAATTCCCTACCTCTCTTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT193592 WP_000344800.1 NZ_CP070232:3403546-3403920 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT193592 NZ_CP093034:c1669371-1669183 [Bartonella krasnovii]
ATGAAAAACACCCTTTCTCCGTTCATTTCAGAGTTCGAAACCGTTGAACAGGAAAGCAGCCACACGGCGTGGTTGCGCGA
TAAGGTCGCGATAAGTCTTGCAAACCTATCTCCTCCTATTCCGCATGATGAGGTCATGGCTGAAATGGACGTTATAATCA
GTCAGCTTGAAAATGAACAGAAAAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References