Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 1774969..1775800 | Replicon | chromosome |
| Accession | NZ_CP070232 | ||
| Organism | Escherichia coli strain 10R | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | - |
| Locus tag | JTF63_RS08385 | Protein ID | WP_039268420.1 |
| Coordinates | 1774969..1775343 (-) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | F4THW5 |
| Locus tag | JTF63_RS08390 | Protein ID | WP_001313071.1 |
| Coordinates | 1775432..1775800 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JTF63_RS08345 | 1770365..1771531 | + | 1167 | WP_001310935.1 | serine-type D-Ala-D-Ala carboxypeptidase DacD | - |
| JTF63_RS08350 | 1771650..1772123 | + | 474 | WP_001105393.1 | DNA gyrase inhibitor SbmC | - |
| JTF63_RS08355 | 1772321..1773379 | + | 1059 | WP_001200905.1 | FUSC family protein | - |
| JTF63_RS08360 | 1773551..1773880 | + | 330 | WP_000450409.1 | DUF496 family protein | - |
| JTF63_RS08365 | 1773981..1774163 | - | 183 | WP_001016348.1 | hypothetical protein | - |
| JTF63_RS08370 | 1774217..1774363 | + | 147 | Protein_1633 | transposase domain-containing protein | - |
| JTF63_RS08375 | 1774652..1774765 | - | 114 | WP_001161660.1 | DUF957 domain-containing protein | - |
| JTF63_RS08380 | 1774778..1774972 | - | 195 | WP_000988600.1 | hypothetical protein | - |
| JTF63_RS08385 | 1774969..1775343 | - | 375 | WP_039268420.1 | type IV toxin-antitoxin system toxin CbtA | Toxin |
| JTF63_RS08390 | 1775432..1775800 | - | 369 | WP_001313071.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| JTF63_RS08395 | 1775880..1776101 | - | 222 | WP_000692301.1 | DUF987 domain-containing protein | - |
| JTF63_RS08400 | 1776164..1776640 | - | 477 | WP_001186726.1 | RadC family protein | - |
| JTF63_RS08405 | 1776656..1777135 | - | 480 | WP_000860076.1 | antirestriction protein | - |
| JTF63_RS08410 | 1777217..1778038 | - | 822 | WP_001234530.1 | DUF945 domain-containing protein | - |
| JTF63_RS08415 | 1778259..1778528 | - | 270 | WP_000995808.1 | hypothetical protein | - |
| JTF63_RS08420 | 1778607..1779304 | - | 698 | Protein_1643 | IS1-like element IS1A family transposase | - |
| JTF63_RS08425 | 1779929..1780474 | + | 546 | WP_000973176.1 | bifunctional adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 14000.00 Da Isoelectric Point: 7.1333
>T193580 WP_039268420.1 NZ_CP070232:c1775343-1774969 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINNIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINNIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
Download Length: 375 bp
>T193580 NZ_CP070232:c1775343-1774969 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACTCCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCCGGCATTTCACTGTGCGATGCAGTGAACTTTCTTGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGCTCTCAGTTAATAAACAACATCGATATCCTCCGGGCTCGCCGGGCGACTGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACTCCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCCGGCATTTCACTGTGCGATGCAGTGAACTTTCTTGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGCTCTCAGTTAATAAACAACATCGATATCCTCCGGGCTCGCCGGGCGACTGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13498.23 Da Isoelectric Point: 5.8696
>AT193580 WP_001313071.1 NZ_CP070232:c1775800-1775432 [Escherichia coli]
VSDTLSGTTHPDDNNSHPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN
VSDTLSGTTHPDDNNSHPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN
Download Length: 369 bp
>AT193580 NZ_CP070232:c1775800-1775432 [Escherichia coli]
GTGTCAGACACACTCTCCGGGACAACTCATCCCGATGACAACAACAGCCACCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCCTGTCTGGTGCAGGAGGGTAACCGGTTGCATTATCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
GTGTCAGACACACTCTCCGGGACAACTCATCCCGATGACAACAACAGCCACCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCCTGTCTGGTGCAGGAGGGTAACCGGTTGCATTATCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|