Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsxAB/Xre(antitoxin) |
| Location | 34183..34684 | Replicon | plasmid unnamed2 |
| Accession | NZ_CP070231 | ||
| Organism | Escherichia coli strain EC12 | ||
Toxin (Protein)
| Gene name | TsxA | Uniprot ID | A0A6X6XTU7 |
| Locus tag | JTC67_RS25980 | Protein ID | WP_000702245.1 |
| Coordinates | 34424..34684 (-) | Length | 87 a.a. |
Antitoxin (Protein)
| Gene name | TsxB | Uniprot ID | - |
| Locus tag | JTC67_RS25975 | Protein ID | WP_001132407.1 |
| Coordinates | 34183..34434 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JTC67_RS25930 (JTC67_25745) | 29472..30179 | + | 708 | WP_000108794.1 | hypothetical protein | - |
| JTC67_RS25935 | 30199..30339 | + | 141 | Protein_26 | hypothetical protein | - |
| JTC67_RS25940 (JTC67_25750) | 30316..30639 | + | 324 | WP_223666488.1 | hypothetical protein | - |
| JTC67_RS25945 (JTC67_25755) | 30641..30967 | + | 327 | WP_000206697.1 | hypothetical protein | - |
| JTC67_RS25950 (JTC67_25760) | 31227..31526 | - | 300 | WP_233679829.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| JTC67_RS25955 | 31767..32210 | + | 444 | WP_023223351.1 | hypothetical protein | - |
| JTC67_RS25960 (JTC67_25770) | 32298..32645 | - | 348 | WP_000681609.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| JTC67_RS25965 (JTC67_25775) | 32642..32890 | - | 249 | WP_000513532.1 | type II toxin-antitoxin system HicA family toxin | - |
| JTC67_RS25970 (JTC67_25780) | 33355..33633 | - | 279 | WP_000545937.1 | hypothetical protein | - |
| JTC67_RS25975 (JTC67_25785) | 34183..34434 | - | 252 | WP_001132407.1 | transcriptional regulator | Antitoxin |
| JTC67_RS25980 (JTC67_25790) | 34424..34684 | - | 261 | WP_000702245.1 | hypothetical protein | Toxin |
| JTC67_RS25985 (JTC67_25795) | 34736..34960 | - | 225 | WP_000814383.1 | hypothetical protein | - |
| JTC67_RS25990 (JTC67_25800) | 35058..35267 | - | 210 | WP_000866037.1 | hypothetical protein | - |
| JTC67_RS25995 (JTC67_25805) | 35308..35631 | - | 324 | WP_233679830.1 | hypothetical protein | - |
| JTC67_RS26000 (JTC67_25810) | 36212..36541 | - | 330 | WP_000855121.1 | hypothetical protein | - |
| JTC67_RS26005 (JTC67_25815) | 37139..37804 | + | 666 | WP_000532148.1 | division plane positioning ATPase MipZ | - |
| JTC67_RS26010 (JTC67_25820) | 37878..38162 | + | 285 | WP_001162371.1 | hypothetical protein | - |
| JTC67_RS26015 (JTC67_25825) | 38180..38776 | - | 597 | WP_000125164.1 | ProQ/FINO family protein | - |
| JTC67_RS26020 (JTC67_25830) | 38926..39045 | - | 120 | WP_227525580.1 | Hok/Gef family protein | - |
| JTC67_RS26025 | 38993..39145 | - | 153 | Protein_44 | FlmC family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | - | - | 1..58414 | 58414 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 87 a.a. Molecular weight: 9818.23 Da Isoelectric Point: 9.5163
>T193573 WP_000702245.1 NZ_CP070231:c34684-34424 [Escherichia coli]
MKIRKGDRQYYLNKEGDTFHLVKRVKTFSKSATLGKTKATVKTVADLVFHEEAFDTIDFASDGLRENDKEIVSMMIQEMS
EGKNAK
MKIRKGDRQYYLNKEGDTFHLVKRVKTFSKSATLGKTKATVKTVADLVFHEEAFDTIDFASDGLRENDKEIVSMMIQEMS
EGKNAK
Download Length: 261 bp
>T193573 NZ_CP093030:c5895231-5894953 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTAGGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTAGGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9404.77 Da Isoelectric Point: 9.8120
>AT193573 WP_001132407.1 NZ_CP070231:c34434-34183 [Escherichia coli]
MPNENTPENIKRLRQKIGLTQKECAEIFSMSPRTWRRKEEPVGTASGTALTPVEFKFLLLLAGEHPDYVLCKRNKKNSDS
GSN
MPNENTPENIKRLRQKIGLTQKECAEIFSMSPRTWRRKEEPVGTASGTALTPVEFKFLLLLAGEHPDYVLCKRNKKNSDS
GSN
Download Length: 252 bp
>AT193573 NZ_CP093030:c5894941-5894636 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|