Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/ElaA-DUF1778
Location 49379..50139 Replicon plasmid unnamed1
Accession NZ_CP070230
Organism Escherichia coli strain EC12

Toxin (Protein)


Gene name tacT Uniprot ID A0A8H9BF00
Locus tag JTC67_RS25095 Protein ID WP_062859951.1
Coordinates 49379..49867 (-) Length 163 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag JTC67_RS25100 Protein ID WP_073534343.1
Coordinates 49855..50139 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JTC67_RS25085 (45954) 45954..46814 + 861 WP_062859948.1 alpha/beta hydrolase -
JTC67_RS25090 (47773) 47773..48396 - 624 Protein_61 ProQ/FINO family protein -
JTC67_RS25095 (49379) 49379..49867 - 489 WP_062859951.1 GNAT family N-acetyltransferase Toxin
JTC67_RS25100 (49855) 49855..50139 - 285 WP_073534343.1 DUF1778 domain-containing protein Antitoxin
JTC67_RS25105 (51054) 51054..51911 - 858 WP_062859953.1 incFII family plasmid replication initiator RepA -
JTC67_RS25110 (51904) 51904..51978 - 75 WP_062859978.1 RepA leader peptide Tap -
JTC67_RS25115 (52221) 52221..52469 - 249 WP_000083839.1 replication regulatory protein RepA -
JTC67_RS25120 (52709) 52709..53299 - 591 WP_062859954.1 DUF2726 domain-containing protein -
JTC67_RS25125 (53338) 53338..53547 - 210 WP_001299729.1 hemolysin expression modulator Hha -
JTC67_RS25130 (53593) 53593..54054 - 462 Protein_69 thermonuclease family protein -
JTC67_RS25135 (54300) 54300..54512 - 213 WP_062859955.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - bfpK / bfpJ / bfpI / bfpH / bfpP / bfpF / bfpE / bfpD / bfpU / bfpC / bfpB / bfpG / bfpA 1..163194 163194


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(27-152)

Antitoxin

Vibrio phage ICP1, Orf50

(12-88)


Sequences

Toxin        


Download         Length: 163 a.a.        Molecular weight: 17614.34 Da        Isoelectric Point: 9.8566

>T193567 WP_062859951.1 NZ_CP070230:c49867-49379 [Escherichia coli]
MGGVTAPEPLSSFHQAAEFVSGEAVLDDWLKQKGLKNQALGATRTFVVCRKGSQQIVGFYSLATGSVNHTEAAGNLRRNM
PDPIPVIILARLAVDVSFRGKGLGADLLHDAVCRCYRVAENIGVRAIMVHALTENAKQFYIHHGFKPSKSQEQTLFLKLP
GK

Download         Length: 489 bp

>T193567 NZ_CP093030:1941354-1941941 [Pseudomonas aeruginosa]
ATGTCGAGGAGGGCGCCCATGTTCAAGCCGCTACCGATCACCCTGCAGCGCGGAGCCTTGCGTCTCGAGCCGCTGGTGGA
AGCGGACATTCCCGAGCTGGTGAGCCTCGCCGAAGCCAACCGCGAGGCGCTGCAGTACATGGACGGACCGACGCGGCCGG
ACTGGTACCGCCAGAGCCTCGCCGAGCAGCGCGAGGGCAGGGCGTTGCCGCTCGCCGTCCGCCTCGGCGTGCAACTGGTC
GGGACCACGCGCTTCGCCGAATTCCTTCCCGCCTTGCCGGCCTGCGAGATCGGCTGGACCTGGCTCGACCAGGCCCAGCA
CGGCAGCGGCCTGAACCGCATGATCAAGTACCTGATGCTCAAGCATGCCTTCGACAACCTGCGCATGGTCCGCGTGCAGC
TCAGCACGGCGGCGAGCAACCTGCGCGCCCAGGGCGCCATCGACAAGCTCGGCGCGCAGCGCGAGGGCGTGCTGCGCAAC
CACCGGCGGCTGGCCGGCGGGCGGCTAGACGACACCTTCGTCTACAGCATCACCGACCACGAATGGCCGCAGGTCAAGGC
GGCGCTGGAAGCCAGCTTCACCGGCTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10947.62 Da        Isoelectric Point: 4.7037

>AT193567 WP_073534343.1 NZ_CP070230:c50139-49855 [Escherichia coli]
MIYGGFMKSGVQLNLRARESQRILIDTAAEILHKSRTDFILEMACKAAEDIILDRRVFNFNDRQYEEFIEMLDAPVADET
AIEKLLARKPQWEV

Download         Length: 285 bp

>AT193567 NZ_CP093030:1942008-1942862 [Pseudomonas aeruginosa]
GTGCCGGACGAGACGAGCGGAGAACACACGCATTTCTGGCGCGCCGCCGAACTGGGCGGCGTCGAACTGCTGCACGCGCG
CTATGTGGAGCAGCGCTTCGCGCCGCACGTGCACAGCAGCTTCGCCCTGGTCATCATCGAGCAGGGCGCGCAGCGCTTCC
GCCATCGTGGCGGCGAGCACCTGGCCCCGCTGGGCAGCATGGTGCTGATCAACCCCGACGAAGTGCACACCGGCTCCAAG
GCCCATGATGCCGGTTGGCTCTATCGCGGCTACTACCCGGAAATGGAACAGATCGACGGGATTCTCGACGAGCTGGAAAT
CCATCATGGCGGCGTGCCGCGTTTCGCCGACAGCGTGATCCACGACCAGCCCCTGGCACGCGCCTTCGTCCACTTGCACC
GCCTGCTGGCCGAGCATGCCGGCAGCCTGGAAACCCAGACCCGCTGGCGCGAGACGATGCTCGCCCTGTTCCGTCGCCAC
GCCCGCCTGCCAGAAGCGCCGAAGGCCGGGCAGGAGCCGTTGGCGGTGGCCCGCGCCCGCGAACTGCTGGCGGCGCGGTT
GCTCGATCCGCCTTCGCTGGAGGAACTGGCGGCGGCGGTCAATCTGTCCCCGTTCCATTTTGCCCGGGTCTTCCGTCGCG
CCACCGGCATGCCGCCCCACGCCTGGCTCAGGCAGCGCCGCCTGGAGCAGGCCAGGGCACTGCTCAAGAGCGGCCGGGCG
CCGCTGGAGGTGGCCCTGGAGCTGGGCTTCGCCGACCAGAGCCACCTCGGTCGCCAGTTCAAGCAGGCCTACGGGGTGGC
ACCGGGTGAATACCGCTCGGCCTGCGCGCGCTCGTCCTTGACGACATACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References