Detailed information of TA system TA193556

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 2548871..2549796
• Replicon: chromosome
• Accession: NZ_CP070229
• Organism: Escherichia coli strain EC12

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: JTC67_RS13085
• Protein ID: WP_014640052.1
• Coordinates: 2548871..2549257 (-)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: -
• Locus tag: JTC67_RS13090
• Protein ID: WP_024174200.1
• Coordinates: 2549287..2549796 (-)
• Length: 170 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JTC67_RS13045 (2544641)	2544641..2545003	+	363	WP_136746472.1	protein YfdP	-
JTC67_RS13050 (2545069)	2545069..2545893	+	825	WP_000081284.1	DUF2303 family protein	-
JTC67_RS13055 (2546022)	2546022..2546558	+	537	WP_000008178.1	5'-deoxynucleotidase	-
JTC67_RS13060 (2546549)	2546549..2546911	+	363	WP_001242725.1	hypothetical protein	-
JTC67_RS13065 (2546911)	2546911..2547720	+	810	WP_074464833.1	hypothetical protein	-
JTC67_RS13070 (2547720)	2547720..2548292	+	573	WP_024207599.1	3'-5' exonuclease	-
JTC67_RS13075 (2548329)	2548329..2548610	+	282	WP_001093916.1	pyocin activator PrtN family protein	-
JTC67_RS13080 (2548658)	2548658..2548831	-	174	WP_021559700.1	hypothetical protein	-
JTC67_RS13085 (2548871)	2548871..2549257	-	387	WP_014640052.1	hypothetical protein	Toxin
JTC67_RS13090 (2549287)	2549287..2549796	-	510	WP_024174200.1	Panacea domain-containing protein	Antitoxin
JTC67_RS13095 (2550331)	2550331..2550846	+	516	WP_000416264.1	zinc uptake transcriptional repressor Zur	-
JTC67_RS13100 (2550888)	2550888..2551097	-	210	WP_001296638.1	CsbD family protein	-
JTC67_RS13105 (2551213)	2551213..2552538	-	1326	WP_001296637.1	MATE family efflux transporter DinF	-
JTC67_RS13110 (2552611)	2552611..2553219	-	609	WP_000646078.1	transcriptional repressor LexA	-
JTC67_RS13115 (2553329)	2553329..2553697	-	369	WP_000002899.1	diacylglycerol kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2506990..2553219	46229

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (6-116)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14465.40 Da
• Isoelectric Point: 5.4833

>T193556 WP_014640052.1 NZ_CP070229:c2549257-2548871 [Escherichia coli]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE

Nucleotide

• Length: 387 bp

>T193556 NZ_CP093028:c151213-150932 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCCCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCTTTTCGGGTAAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTAA

Antitoxin

Protein

• Length: 170 a.a.
• Molecular weight: 19559.39 Da
• Isoelectric Point: 5.3338

>AT193556 WP_024174200.1 NZ_CP070229:c2549796-2549287 [Escherichia coli]
MAYLKLMKLLYLSNRKSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYNLIETNGHDVLLRSDPREMDAD
EVFDELSRADIRILDEIYSLYGHMNRFDLANMTHLESVCPEWHNPGNSRKPIDLKEMLISEGKSEDEANRIIGKMEESQK
LKEFSLQLS

Nucleotide

• Length: 510 bp

>AT193556 NZ_CP093028:c151437-151210 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCTGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCGTATCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA