Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3996960..3997614 Replicon chromosome
Accession NZ_CP070227
Organism Escherichia coli strain JA0072

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag JS570_RS18920 Protein ID WP_000244781.1
Coordinates 3996960..3997367 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag JS570_RS18925 Protein ID WP_000354046.1
Coordinates 3997348..3997614 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JS570_RS18900 (3992917) 3992917..3994650 - 1734 WP_000813193.1 single-stranded-DNA-specific exonuclease RecJ -
JS570_RS18905 (3994656) 3994656..3995366 - 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JS570_RS18910 (3995391) 3995391..3996287 - 897 WP_000806633.1 site-specific tyrosine recombinase XerD -
JS570_RS18915 (3996399) 3996399..3996920 + 522 WP_001055874.1 flavodoxin FldB -
JS570_RS18920 (3996960) 3996960..3997367 - 408 WP_000244781.1 protein YgfX Toxin
JS570_RS18925 (3997348) 3997348..3997614 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
JS570_RS18930 (3997857) 3997857..3998837 + 981 WP_000886078.1 tRNA-modifying protein YgfZ -
JS570_RS18935 (3998914) 3998914..3999573 - 660 WP_000250274.1 hemolysin III family protein -
JS570_RS18940 (3999737) 3999737..4000048 - 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
JS570_RS18945 (4000093) 4000093..4001526 + 1434 WP_001350137.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T193536 WP_000244781.1 NZ_CP070227:c3997367-3996960 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T193536 NZ_CP093020:c5095159-5094632 [Pseudomonas aeruginosa]
ATGATCCTCCTCGACCTGCCGCCCGGCACCACGCTGTTTCGCGCGCACACCCCGCAGTGGGCCAGCCGGCCAACCAGCGG
CGCTGGTGCGGCGGCCAAGGGCGGGCGCTTCAACCGGGAGGGCGTCGAGGCGCTGTATCTGTCGCTGGAGGAAGCGACCG
CGCTACGCGAATACCAGCAGACCTCGCCCTTCCTGCCGCCCTGCACGATGTGCTCGTACACCGTGGCATTGCGCGAGCTG
GTCGATCTGCGGCAGCTCCACCGCGGCGAACCTTGGGACGAGCTGTGGCACGACTGGCGCGAGGACTGGCGCCATCTGAA
ATTCGACCTTCACATCGAGCCGCCCACTTGGGTGCTGGGCGACATGGTGCTGGCCCAGGGCCATACCGGAATCCTGTTCC
CCAGCCAGGCGAACGATGGCGGCACCAATATCGTGGTGTTCGTGGATCGGCTCAGGGATGGCAATTCGGTCGAGGTCAAT
GATCCCGACGGGCGACTGCCCCGCGACCAATCCAGTTGGACGCGCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT193536 WP_000354046.1 NZ_CP070227:c3997614-3997348 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT193536 NZ_CP093020:c5095527-5095156 [Pseudomonas aeruginosa]
ATGGCCTCTACCGCTTTCGCGGATGTGCTCGAATCGGTGCGTGAAGCCGGCACGTCCCGCTTTTCCGCCACGAACGTCGC
CGATGCCCTGGGCCTGCAGTACCAGGACTTGGCCACGCTGGCTGGCGTGCACCGCAACACCCTGCGCACCCACCCCGAGT
CACCGCGACTCCAGGCCGCGCTTCGTGACCTGATGCGGGTGCTATCGGCCGCCTCGGCGGTGCAGCCGGATACCGCGCGT
GCATTCTTCATGGTCAAGAACGAGCCCATCCCGACGTTCCACCACAAGACCCTGCTGCAGTTGGTGCAGGAAGGACGCAC
CGACGATGCGATCGACTACCTGGAGTCGATCAGTGCAGGGTTCACCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References