193511

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 86321..86846 Replicon plasmid unnamed1
Accession NZ_CP070173
Organism Klebsiella pneumoniae strain FDAARGOS_1315

Toxin (Protein)


Gene name ccdB Uniprot ID A0A7H9GHC5
Locus tag I6K45_RS25855 Protein ID WP_009309918.1
Coordinates 86541..86846 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A1D8K3R4
Locus tag I6K45_RS25850 Protein ID WP_006788213.1
Coordinates 86321..86539 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K45_RS25825 82447..83469 - 1023 WP_204745902.1 DNA helicase UvrD -
I6K45_RS25830 83454..85016 - 1563 WP_009309907.1 AAA family ATPase -
I6K45_RS25835 85090..85506 - 417 WP_001044770.1 type II toxin-antitoxin system VapC family toxin -
I6K45_RS25840 85503..85733 - 231 WP_001261282.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
I6K45_RS25845 85690..86151 + 462 WP_075210108.1 hypothetical protein -
I6K45_RS25850 86321..86539 + 219 WP_006788213.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
I6K45_RS25855 86541..86846 + 306 WP_009309918.1 type II toxin-antitoxin system toxin CcdB Toxin
I6K45_RS25860 87265..87600 + 336 WP_009309920.1 hypothetical protein -
I6K45_RS25865 87634..88650 + 1017 WP_009309921.1 hypothetical protein -
I6K45_RS25870 88848..89627 + 780 WP_023287113.1 site-specific integrase -
I6K45_RS25875 89685..89942 - 258 WP_009310077.1 hypothetical protein -
I6K45_RS25880 90071..90184 - 114 WP_014343462.1 hypothetical protein -
I6K45_RS25885 90716..91684 - 969 WP_000654811.1 IS5 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - mrkJ / mrkF / mrkD / mrkC / mrkB / mrkA / mrkJ / mrkF / mrkD / mrkC / mrkB / mrkA / mrkJ / mrkF / mrkD / mrkD / mrkC / mrkB / mrkA 1..253456 253456
- flank IS/Tn - - 81217..82185 968


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11571.24 Da        Isoelectric Point: 6.4661

>T193511 WP_009309918.1 NZ_CP070173:86541-86846 [Klebsiella pneumoniae]
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVVPLASARLLSDKVSRELYPVVHIGDDSYRLMTTDMASVTASVTGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

>T193511 NZ_CP093014:c5316276-5315998 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8362.31 Da        Isoelectric Point: 4.7405

>AT193511 WP_006788213.1 NZ_CP070173:86321-86539 [Klebsiella pneumoniae]
MKQRITVTIDSDSYQLLKSADVNISGLVNRAMQNEARRLRAERWQAENQEGMAEVARFIEMNGSFADENRDW

Download         Length: 219 bp

>AT193511 NZ_CP093014:c5315986-5315681 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTTGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H9GHC5

Antitoxin

Source ID Structure
AlphaFold DB A0A1D8K3R4

References