193498

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2113860..2114479 Replicon chromosome
Accession NZ_CP070172
Organism Klebsiella pneumoniae strain FDAARGOS_1315

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag I6K45_RS10285 Protein ID WP_002892050.1
Coordinates 2113860..2114078 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag I6K45_RS10290 Protein ID WP_002892066.1
Coordinates 2114105..2114479 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K45_RS10250 2109907..2110170 + 264 WP_002892011.1 type B 50S ribosomal protein L31 -
I6K45_RS10255 2110170..2110310 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
I6K45_RS10260 2110307..2111005 - 699 WP_002892021.1 GNAT family N-acetyltransferase -
I6K45_RS10265 2111106..2112557 + 1452 WP_204745874.1 aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme -
I6K45_RS10270 2112532..2113002 - 471 WP_002892026.1 YlaC family protein -
I6K45_RS10275 2113023..2113163 + 141 WP_004147370.1 hypothetical protein -
I6K45_RS10280 2113135..2113701 - 567 WP_002892030.1 maltose O-acetyltransferase -
I6K45_RS10285 2113860..2114078 - 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
I6K45_RS10290 2114105..2114479 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
I6K45_RS10295 2114965..2118111 - 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
I6K45_RS10300 2118134..2119327 - 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T193498 WP_002892050.1 NZ_CP070172:c2114078-2113860 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T193498 NZ_CP093011:c4827895-4827518 [Escherichia coli]
ATGAAAACATTACCTGATACACACGTACGGAAGGTATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGTACCGACCTGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGATCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT193498 WP_002892066.1 NZ_CP070172:c2114479-2114105 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT193498 NZ_CP093011:c4828352-4827984 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAATTAATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGACTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGTTACGTTTATCTGGCTTTTTATCCAACATCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References