Detailed information of TA system TA193496

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 1481769..1482472
• Replicon: chromosome
• Accession: NZ_CP070172
• Organism: Klebsiella pneumoniae strain FDAARGOS_1315

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: I6K45_RS07240
• Protein ID: WP_049190347.1
• Coordinates: 1482131..1482472 (+)
• Length: 114 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: I6K45_RS07235
• Protein ID: WP_075210061.1
• Coordinates: 1481769..1482110 (+)
• Length: 114 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K45_RS07195	1477302..1478006	+	705	WP_049190322.1	WYL domain-containing protein	-
I6K45_RS07200	1478006..1478575	+	570	WP_049190325.1	hypothetical protein	-
I6K45_RS07205	1478612..1479064	+	453	WP_049190329.1	hypothetical protein	-
I6K45_RS07210	1479061..1479510	+	450	WP_014226752.1	hypothetical protein	-
I6K45_RS07215	1479582..1479812	+	231	WP_049190333.1	DUF905 domain-containing protein	-
I6K45_RS07220	1479911..1480732	+	822	WP_049190336.1	DUF945 domain-containing protein	-
I6K45_RS07225	1480763..1481203	+	441	WP_049190339.1	antirestriction protein	-
I6K45_RS07230	1481216..1481758	+	543	WP_049190342.1	DNA repair protein RadC	-
I6K45_RS07235	1481769..1482110	+	342	WP_075210061.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
I6K45_RS07240	1482131..1482472	+	342	WP_049190347.1	TA system toxin CbtA family protein	Toxin
I6K45_RS07250	1483937..1484944	+	1008	WP_204745864.1	restriction endonuclease	-
I6K45_RS07255	1485277..1486146	-	870	WP_032426715.1	HNH endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1451821..1483788	31967

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-109)

Antitoxin

• Antitoxin CbeA (13-111)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12787.75 Da
• Isoelectric Point: 8.9919

>T193496 WP_049190347.1 NZ_CP070172:1482131-1482472 [Klebsiella pneumoniae]
MKTLPATNPQAAKLCLSPVAVWQMLLARLLEQHYGLTLNDTPFNDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRRGF
DWQEQSPYLRAVDILRARQATGLLKRNRISAAR

Nucleotide

• Length: 342 bp

>T193496 NZ_CP093011:c4580801-4580694 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Protein

• Length: 114 a.a.
• Molecular weight: 12710.38 Da
• Isoelectric Point: 6.7345

>AT193496 WP_075210061.1 NZ_CP070172:1481769-1482110 [Klebsiella pneumoniae]
MKSTDSENDSFLKWGLNRNVAPCFGVRLVQEGNRLHYLADRASITGKFSEAECLKLDVAFPHFISQMESMLTTGEMNPRH
AHCVTLYHNGFTCEADTLGSCGYVYIAVYSTHR

Nucleotide

• Length: 342 bp

>AT193496 NZ_CP093011:4580850-4580916 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC