Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4809873..4810530 Replicon chromosome
Accession NZ_CP070169
Organism Klebsiella pneumoniae strain FDAARGOS_1320

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag I6K50_RS23110 Protein ID WP_002916310.1
Coordinates 4810120..4810530 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag I6K50_RS23105 Protein ID WP_002916312.1
Coordinates 4809873..4810139 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K50_RS23080 4805029..4806462 - 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -
I6K50_RS23085 4806581..4807309 - 729 WP_009485882.1 MurR/RpiR family transcriptional regulator -
I6K50_RS23090 4807359..4807670 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
I6K50_RS23095 4807834..4808493 + 660 WP_002916317.1 hemolysin III family protein -
I6K50_RS23100 4808644..4809627 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
I6K50_RS23105 4809873..4810139 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
I6K50_RS23110 4810120..4810530 + 411 WP_002916310.1 protein YgfX Toxin
I6K50_RS23115 4810537..4811058 - 522 WP_002916308.1 flavodoxin FldB -
I6K50_RS23120 4811159..4812055 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
I6K50_RS23125 4812078..4812791 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
I6K50_RS23130 4812797..4814530 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T193458 WP_002916310.1 NZ_CP070169:4810120-4810530 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T193458 NZ_CP092982:c52927-52550 [Mycobacterium marinum]
GTGACCGAATACCCCACAGTCGATGATGTGCTGATCGTCGCAGAGTATGCCTGCGGCTTCCGTCCTCTGGTCAGCGACCC
AGGTCTATTCGAGTCGAGTCTGATGCGCCCAGCGGCAACAGTTTTCGGTAGCGACGCCTACCCGACTGTGTGGGATAAGG
CGGCAGCGCTGCTGCATTCGTTCGTGACGACGCAGTCGCTGGCCGATGGAAACAAGCGGACAGGCTGGGCTGCGTGCTGG
CTTCTACTTGGCCTCAATGGGCACCGGCTATCTGCGGCCCTTGACGTCGATGCGGCCGAGAAGTTCGTTCTTGCTATCGC
TGGCGGCGAACTAGCTTGGGAACAGATCGCAGCTCGACTGCCCGATTTCGCAGATTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT193458 WP_002916312.1 NZ_CP070169:4809873-4810139 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT193458 NZ_CP092982:c53121-52924 [Mycobacterium marinum]
ATGCCGGCGTTGAATGTCGATTTTTCCGACGAGGAACTGGCGATCGTGCGGTCGGCGGCGAGCAACGCCGGCGCGTCGAT
GCGTGGCTTTGCAAAGCAAGCGATCCTGGACAAGGCAGTTGACCGGGCCGGGCGAGTGCACGCCCTCGGGCGAGAGATCG
CGGATCGGTCGGCTGAACTGAATCGCCGGTTAGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References