Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2707805..2708424 Replicon chromosome
Accession NZ_CP070169
Organism Klebsiella pneumoniae strain FDAARGOS_1320

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag I6K50_RS12935 Protein ID WP_002892050.1
Coordinates 2708206..2708424 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag I6K50_RS12930 Protein ID WP_002892066.1
Coordinates 2707805..2708179 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K50_RS12920 2702957..2704150 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
I6K50_RS12925 2704173..2707319 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
I6K50_RS12930 2707805..2708179 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
I6K50_RS12935 2708206..2708424 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
I6K50_RS12940 2708583..2709149 + 567 WP_002892030.1 maltose O-acetyltransferase -
I6K50_RS12945 2709121..2709261 - 141 WP_004147370.1 hypothetical protein -
I6K50_RS12950 2709282..2709752 + 471 WP_002892026.1 YlaC family protein -
I6K50_RS12955 2709727..2711133 - 1407 WP_020316531.1 PLP-dependent aminotransferase family protein -
I6K50_RS12960 2711278..2711976 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
I6K50_RS12965 2711973..2712113 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
I6K50_RS12970 2712113..2712376 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T193452 WP_002892050.1 NZ_CP070169:2708206-2708424 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T193452 NZ_CP092973:c4310435-4310262 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT193452 WP_002892066.1 NZ_CP070169:2707805-2708179 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT193452 NZ_CP092973:c4310759-4310463 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References