Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2564009..2564487 Replicon chromosome
Accession NZ_CP070162
Organism Escherichia coli strain FDAARGOS_1283

Toxin (Protein)


Gene name parE_1 Uniprot ID D8A5B3
Locus tag I6K13_RS12800 Protein ID WP_000936799.1
Coordinates 2564200..2564487 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID D8A5B4
Locus tag I6K13_RS12795 Protein ID WP_000100899.1
Coordinates 2564009..2564200 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K13_RS12745 (2559077) 2559077..2559433 - 357 WP_021538043.1 hypothetical protein -
I6K13_RS12750 (2559411) 2559411..2559872 - 462 WP_001209475.1 sigma-E factor regulatory protein RseB domain-containing protein -
I6K13_RS12755 (2559869) 2559869..2560165 - 297 WP_024188212.1 DUF4406 domain-containing protein -
I6K13_RS12760 (2560162) 2560162..2560479 - 318 WP_021538045.1 hypothetical protein -
I6K13_RS12765 (2560476) 2560476..2561192 - 717 WP_100272965.1 DUF1627 domain-containing protein -
I6K13_RS12770 (2561226) 2561226..2561687 - 462 WP_000139447.1 replication protein P -
I6K13_RS12775 (2561680) 2561680..2562717 - 1038 WP_021538047.1 DnaT-like ssDNA-binding domain-containing protein -
I6K13_RS12780 (2562789) 2562789..2563214 - 426 WP_000693918.1 toxin YdaT family protein -
I6K13_RS12785 (2563198) 2563198..2563470 - 273 WP_000887447.1 YdaS family helix-turn-helix protein -
I6K13_RS12790 (2563580) 2563580..2563981 + 402 WP_001329851.1 helix-turn-helix domain-containing protein -
I6K13_RS12795 (2564009) 2564009..2564200 + 192 WP_000100899.1 hypothetical protein Antitoxin
I6K13_RS12800 (2564200) 2564200..2564487 + 288 WP_000936799.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6K13_RS12805 (2564761) 2564761..2564913 + 153 WP_021538048.1 DUF1391 family protein -
I6K13_RS12810 (2564925) 2564925..2565263 + 339 WP_000394541.1 hypothetical protein -
I6K13_RS12815 (2565252) 2565252..2565446 - 195 WP_001295058.1 hypothetical protein -
I6K13_RS12820 (2566022) 2566022..2566210 + 189 WP_000449172.1 cell division inhibition protein DicB -
I6K13_RS12825 (2566207) 2566207..2566395 + 189 WP_000199480.1 DUF1482 family protein -
I6K13_RS12830 (2566491) 2566491..2568965 + 2475 WP_021538049.1 exonuclease -
I6K13_RS12835 (2569024) 2569024..2569227 + 204 WP_000096346.1 DUF4224 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10929.85 Da        Isoelectric Point: 10.1360

>T193435 WP_000936799.1 NZ_CP070162:2564200-2564487 [Escherichia coli]
MLPILWLPSARDDLRQIVAYIAKENIPAARRLKIRIETSVLALSEHPYLYPPSDRVSGLREIVVHPNYIVLYRVATSSIE
IANIVHARRQFPFPI

Download         Length: 288 bp

>T193435 NZ_CP092973:721934-722230 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7035.80 Da        Isoelectric Point: 4.0270

>AT193435 WP_000100899.1 NZ_CP070162:2564009-2564200 [Escherichia coli]
MSTALSPIVSEFETTEQENSYNEWLRAKVASSLADPRPSIPHDEVMAEMENLIAQIAVTNRSE

Download         Length: 192 bp

>AT193435 NZ_CP092973:722232-722627 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D8A5B3

Antitoxin

Source ID Structure
AlphaFold DB A0A161RC07

References