Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 339313..340145 Replicon chromosome
Accession NZ_CP070162
Organism Escherichia coli strain FDAARGOS_1283

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag I6K13_RS01605 Protein ID WP_204695186.1
Coordinates 339771..340145 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag I6K13_RS01600 Protein ID WP_001598216.1
Coordinates 339313..339681 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K13_RS01580 (337057) 337057..337875 + 819 WP_001598214.1 DUF932 domain-containing protein -
I6K13_RS01585 (337967) 337967..338452 + 486 WP_000213700.1 antirestriction protein -
I6K13_RS01590 (338467) 338467..338943 + 477 WP_162744079.1 RadC family protein -
I6K13_RS01595 (339012) 339012..339233 + 222 WP_000692303.1 DUF987 domain-containing protein -
I6K13_RS01600 (339313) 339313..339681 + 369 WP_001598216.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
I6K13_RS01605 (339771) 339771..340145 + 375 WP_204695186.1 TA system toxin CbtA family protein Toxin
I6K13_RS01610 (340142) 340142..340633 + 492 WP_001598218.1 DUF5983 family protein -
I6K13_RS01615 (340645) 340645..340842 + 198 WP_024192776.1 DUF957 domain-containing protein -
I6K13_RS01620 (340927) 340927..341076 + 150 Protein_322 hypothetical protein -
I6K13_RS01625 (342032) 342032..344068 + 2037 WP_195390145.1 hypothetical protein -
I6K13_RS01630 (344467) 344467..344646 - 180 Protein_324 peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimB / fimE 305660..351792 46132


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13841.81 Da        Isoelectric Point: 7.9086

>T193416 WP_204695186.1 NZ_CP070162:339771-340145 [Escherichia coli]
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAK

Download         Length: 375 bp

>T193416 NZ_CP092968:c1217761-1217507 [Methylocystis parvus OBBP]
ATGAAGCTCGTCTTTGCGGAACAGGCCTGGGAGGATTACCTCTACTGGCAGTCGCAGGACGCGAAGGTTCTGGAGCGCAT
TAATTCACTCATCAAGGAATGTGCGCGCACGCCTTTTTCAGGGACGGGAAAGCCCGAGCCGCTACGGGGCGACTTGCGCG
GCTGGTGGTCGCGACGGATCACGCTGGAGCATCGGCTGGTGTATCGCGTTGAAGGCGAGAGCCTGCTGATTGCACAGTGC
AGGTATCATTATTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13605.40 Da        Isoelectric Point: 7.3992

>AT193416 WP_001598216.1 NZ_CP070162:339313-339681 [Escherichia coli]
VSDTLSGTTHPDDNNSHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSRGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT193416 NZ_CP092968:c1218012-1217758 [Methylocystis parvus OBBP]
ATGCGCACCACTTCTTACAGCGATCTCCGCAAGAACCTCGCCGCCACGCTCGACCGCGTGACCGAAGATCATGAGCCGGT
AGTCATCACGCGCGATCGCGGCAAGCCCGCCGCCGTTCTCATTTCGCTCGAGGACTTCGCGTCCTATGAGGAGACCGCGC
ATCTTTTGAAGAATCCGCGCAACGCCGAGCGCCTTCTCGCTGCGATCGGTGAACTGGACGCGGGCAAGGGCGTGGAGCGC
AAGCTCTCGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References