Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 99006..99840 Replicon chromosome
Accession NZ_CP070162
Organism Escherichia coli strain FDAARGOS_1283

Toxin (Protein)


Gene name yeeV Uniprot ID A0A8E0IX31
Locus tag I6K13_RS00505 Protein ID WP_000854689.1
Coordinates 99006..99383 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A8E0IVP8
Locus tag I6K13_RS00510 Protein ID WP_001285599.1
Coordinates 99460..99840 (-) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K13_RS00470 (94253) 94253..95650 + 1398 WP_000404886.1 PTS ascorbate transporter subunit IIC -
I6K13_RS00475 (95666) 95666..95971 + 306 WP_000218362.1 PTS ascorbate transporter subunit IIB -
I6K13_RS00480 (95981) 95981..96445 + 465 WP_000776505.1 PTS ascorbate transporter subunit IIA -
I6K13_RS00485 (96459) 96459..97109 + 651 WP_000056749.1 3-keto-L-gulonate-6-phosphate decarboxylase UlaD -
I6K13_RS00490 (97381) 97381..98228 - 848 Protein_93 DUF4942 domain-containing protein -
I6K13_RS00495 (98313) 98313..98510 - 198 WP_000839236.1 DUF957 domain-containing protein -
I6K13_RS00500 (98522) 98522..99009 - 488 Protein_95 DUF5983 family protein -
I6K13_RS00505 (99006) 99006..99383 - 378 WP_000854689.1 TA system toxin CbtA family protein Toxin
I6K13_RS00510 (99460) 99460..99840 - 381 WP_001285599.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
I6K13_RS00515 (99890) 99890..100534 - 645 WP_000086755.1 hypothetical protein -
I6K13_RS00520 (100553) 100553..100774 - 222 WP_000692345.1 DUF987 domain-containing protein -
I6K13_RS00525 (100843) 100843..101319 - 477 WP_001424026.1 RadC family protein -
I6K13_RS00530 (101335) 101335..101808 - 474 WP_000855059.1 antirestriction protein -
I6K13_RS00535 (102149) 102149..102970 - 822 WP_016244184.1 DUF932 domain-containing protein -
I6K13_RS00540 (103071) 103071..103279 - 209 Protein_103 DUF905 family protein -
I6K13_RS00545 (103380) 103380..103835 - 456 WP_000581506.1 IrmA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - sat 97381..128213 30832


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14042.07 Da        Isoelectric Point: 9.1510

>T193415 WP_000854689.1 NZ_CP070162:c99383-99006 [Escherichia coli]
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

>T193415 NZ_CP092924:27188-27538 [Pseudomonas syringae pv. tagetis]
ATGAATACGTTTGCACTACGCTTTACCGATGTTGCCCAGCAAAGCCTCGAAGATCAGGTTGAACATCTGGCTGTCTATCA
GGGATTCTCATCAGCTGCTCAACGCATAGATTCCCTTATCGATGCCATCCAGGACAAGCTCCTGTCCACCCCGTTGGGCT
ATCCGGTCAGTCCTCAATTGAGTGAGCTGGGCGTACTGCACTATCGTGAGTTGAACACTGACGGATACCGGATCTTTTAC
GAGGTGATGGATTCTGATGGTATTACCGACATCAGCGTATTGCTCGTATTGGGTAGTAAACAGAGTGTTGAACAGGCACT
GATCCGCTACTGTCTGCTACAGCCTATGTAG

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 13984.78 Da        Isoelectric Point: 5.0823

>AT193415 WP_001285599.1 NZ_CP070162:c99840-99460 [Escherichia coli]
MSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLLQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Download         Length: 381 bp

>AT193415 NZ_CP092924:26927-27175 [Pseudomonas syringae pv. tagetis]
ATGCGAGTTGAAACAATAAGCTACCTGAAACGCAATGCAGCCGACCTGCCTCTTGATGAGCCATTGGTCGTCACGCAAAA
CGGTGTCCCGGCCTACGTGGTGGAGTCTTACGCTGATCGTAAGCGCCGCGATGAGTCAATTGCCTTGGTGAAGCTCCTGG
CAATCAGCTCGCGCGAGTACTCCCAAGGCAAGCACTGTTCCACTGACGAACTCAAAGCCCGATTGAGCAGGAGGTTTGCC
CAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References