Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 5226405..5227062 Replicon chromosome
Accession NZ_CP070158
Organism Klebsiella pneumoniae strain FDAARGOS_1310

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag I6K40_RS25080 Protein ID WP_002916310.1
Coordinates 5226405..5226815 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag I6K40_RS25085 Protein ID WP_002916312.1
Coordinates 5226796..5227062 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K40_RS25060 5222405..5224138 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
I6K40_RS25065 5224144..5224857 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
I6K40_RS25070 5224880..5225776 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
I6K40_RS25075 5225877..5226398 + 522 WP_004144730.1 flavodoxin FldB -
I6K40_RS25080 5226405..5226815 - 411 WP_002916310.1 protein YgfX Toxin
I6K40_RS25085 5226796..5227062 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
I6K40_RS25090 5227308..5228291 + 984 WP_020324927.1 tRNA-modifying protein YgfZ -
I6K40_RS25095 5228442..5229101 - 660 WP_002916317.1 hemolysin III family protein -
I6K40_RS25100 5229265..5229576 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
I6K40_RS25105 5229626..5230354 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
I6K40_RS25110 5230473..5231906 + 1434 WP_020324925.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T193412 WP_002916310.1 NZ_CP070158:c5226815-5226405 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T193412 NZ_CP092923:c636295-635651 [Pseudomonas syringae pv. tagetis]
ATGAAGTACAGCAGTCTGAATCCAAAAAAAGCTCTAATTTGGCGTATCGTCCACCGCGATAACCTGCCTTGGATTCTGGA
CAACGGTCTTCATTGCGCCAGCTCAGACGTGCAAGCGCCGCAGTACGTGAACATCGGTAACCTTGACCTGATTGGCAAAC
GCCGCAATCGCGGTGTTCCTATTGCTCCAGCGGGCGTACTGTCCGACTACGTGCCCTTCTACTTCACACCTTTCTCTGTG
ATGATGAAAAATATCCATTCCGGCCGGAGCGTCCAGCAGCGTAGCAATGACGAGATAGTAATTCTGGTTTCAAGCCTGCC
TCGCGTTGAGCAGCTTGGCCTGGCTTTCGTCTTTACCAATGCACACGCCTATCCTGACTGGACCGATTACTATAGCGAGC
TGGCGAGTCTTGACCAGATCGACTGGTCTATAATCCAGAGACGAGACTTCAAGCGTGATCCTGACGATCCGCGTAAGATG
GAGCGTTATCAAGCCGAAGCGCTCATTCACCATCACCTACCGATTACAGGACTCCTTGGCATCATGTGCTACGACGATGC
AATGAAAGAACGCATTGAGCAAGACGTTGCCGCCAGAGGTCTGACCTTGCCTGTCCACGCGCGTCCGGGATGGTATTTCC
AATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT193412 WP_002916312.1 NZ_CP070158:c5227062-5226796 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT193412 NZ_CP092923:c635654-634566 [Pseudomonas syringae pv. tagetis]
ATGATCAGATTCACCCAAGGCAATCTGCTGAAAGCAGATACCGAAGCTCTCGTCAACACGGTGAACACCGTAGGCGTGAT
GGGAAAAGGCATTGCGTTGATGTTCAAGGAGCGCTTTACCGAAAACTATCGCCTCTATTCGGCGGCGTGCAAGGCTGGTG
AGGTAGAGACCGGAAAGGTTCACGTAACGGCAGTCAACGAGCTGGACGGGCCACGCTGGATAGTGAATTTTCCTACCAAG
CGTCACTGGCGCTCCCCCTCGCAGATGGCATGGATAACTGAAGGCTTACGGGACCTGCGCCGCTTTTTGATTGATAACCA
AGTGAAATCCGTAGCAGTTCCACCTCTCGGTGCTGGTAATGGCGGTTTGAAATGGGTAGAGGTCCGTGAGCAGATTGTTG
ATGTCTTGAGTGATCTGGATGTGGATGTACTTGTCTTTGAACCCACCGATCAATATCTGAATGTAGCGAAGCACAGCGGT
GTCGAGAAGCTGACGCCTGCACGTGCACTCATCGCCGAACTCGTTCGGCGTTACTGGGTTTTGGGCATGGAATGTAGCCT
GCTTGAAATTCAGAAGCTCGCTTGGTTTCTGGAGCGTTCGATAGAACAATTGCCAAGCGCAAAGAACCCCTTGGATCTCA
AATTTGTAGCCCACAAATATGGGCCATACGCCAATCGCCTTGAGCATCTACTCGACAATCTCGATGGCAGCTACCTGCAT
TGCGATAAACGCATCAGCGACGCAGGTATTAACGACGTGATCTGGTTTGACGAGGGCCGTAAGGCTTTTCTGCAAACCTA
TCTGAAAACAGAGGCCAAGGAATATTCCCAAGCTCTGGAGCGTACCGCAGAGCTGATTGACGGCTTTGAGTCGCCTTTCG
GTATGGAGTTGTTGGCGACGGTTGACTGGTTATTGAGTAAGTCGGGAGTTTCTCCAACGGTTCCGGCAGTGCGTGAAGCA
TTGAAAAATTGGGATGGAGGCGCAGGTGCGGCGGCTCGGAAAAGCAGGCTGTTCGATGATCAAGCTCTCGGCATTGCGTT
AAAGCGGTTGACTGCTAGCAATCTCAGTCCAGAGATAGCCGTCCCCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References