Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2009881..2010500 Replicon chromosome
Accession NZ_CP070158
Organism Klebsiella pneumoniae strain FDAARGOS_1310

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag I6K40_RS09570 Protein ID WP_002892050.1
Coordinates 2009881..2010099 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag I6K40_RS09575 Protein ID WP_002892066.1
Coordinates 2010126..2010500 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K40_RS09535 2005928..2006191 + 264 WP_002892011.1 type B 50S ribosomal protein L31 -
I6K40_RS09540 2006191..2006331 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
I6K40_RS09545 2006328..2007026 - 699 WP_002892021.1 GNAT family N-acetyltransferase -
I6K40_RS09550 2007127..2008578 + 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
I6K40_RS09555 2008553..2009023 - 471 WP_002892026.1 YlaC family protein -
I6K40_RS09560 2009044..2009184 + 141 WP_004147370.1 hypothetical protein -
I6K40_RS09565 2009156..2009722 - 567 WP_002892030.1 maltose O-acetyltransferase -
I6K40_RS09570 2009881..2010099 - 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
I6K40_RS09575 2010126..2010500 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
I6K40_RS09580 2010986..2014132 - 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
I6K40_RS09585 2014155..2015348 - 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T193401 WP_002892050.1 NZ_CP070158:c2010099-2009881 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T193401 NZ_CP092911:c3733638-3733225 [Salmonella enterica subsp. enterica]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAAAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT193401 WP_002892066.1 NZ_CP070158:c2010500-2010126 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT193401 NZ_CP092911:c3733885-3733619 [Salmonella enterica subsp. enterica]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References