Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1265884..1266400 Replicon chromosome
Accession NZ_CP070158
Organism Klebsiella pneumoniae strain FDAARGOS_1310

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag I6K40_RS06140 Protein ID WP_004178374.1
Coordinates 1266116..1266400 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag I6K40_RS06135 Protein ID WP_002886901.1
Coordinates 1265884..1266126 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K40_RS06120 1261912..1262652 + 741 WP_002886899.1 KDGP aldolase family protein -
I6K40_RS06125 1262719..1263873 + 1155 WP_004178372.1 lactonase family protein -
I6K40_RS06130 1263896..1265806 + 1911 WP_004178373.1 BglG family transcription antiterminator -
I6K40_RS06135 1265884..1266126 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
I6K40_RS06140 1266116..1266400 + 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6K40_RS06145 1266404..1266868 - 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
I6K40_RS06150 1267109..1269247 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
I6K40_RS06155 1269604..1270347 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
I6K40_RS06160 1270350..1270523 - 174 WP_032408826.1 hypothetical protein -
I6K40_RS06165 1270608..1270916 + 309 WP_022631369.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T193399 WP_004178374.1 NZ_CP070158:1266116-1266400 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T193399 NZ_CP092911:c2514988-2514885 [Salmonella enterica subsp. enterica]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT193399 WP_002886901.1 NZ_CP070158:1265884-1266126 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT193399 NZ_CP092911:2514883-2515026 [Salmonella enterica subsp. enterica]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References