Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pmenTA/darT(toxin) |
| Location | 5011274..5012994 | Replicon | chromosome |
| Accession | NZ_CP070157 | ||
| Organism | Escherichia coli strain FDAARGOS_1276 | ||
Toxin (Protein)
| Gene name | pmenT | Uniprot ID | A0A7U9J2A7 |
| Locus tag | I6K06_RS23675 | Protein ID | WP_000312833.1 |
| Coordinates | 5012338..5012994 (-) | Length | 219 a.a. |
Antitoxin (Protein)
| Gene name | pmenA | Uniprot ID | B7UP19 |
| Locus tag | I6K06_RS23670 | Protein ID | WP_000634203.1 |
| Coordinates | 5011274..5012341 (-) | Length | 356 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I6K06_RS23655 (5006485) | 5006485..5007099 | - | 615 | Protein_4660 | IS3-like element IS600 family transposase | - |
| I6K06_RS23660 (5007444) | 5007444..5008160 | - | 717 | WP_001122107.1 | SprT family zinc-dependent metalloprotease | - |
| I6K06_RS23665 (5008160) | 5008160..5011255 | - | 3096 | WP_000108735.1 | HsdR family type I site-specific deoxyribonuclease | - |
| I6K06_RS23670 (5011274) | 5011274..5012341 | - | 1068 | WP_000634203.1 | toxin-antitoxin system antitoxin DNA ADP-ribosyl glycohydrolase DarG | Antitoxin |
| I6K06_RS23675 (5012338) | 5012338..5012994 | - | 657 | WP_000312833.1 | toxin-antitoxin system toxin DNA ADP-ribosyl transferase DarT | Toxin |
| I6K06_RS23680 (5013007) | 5013007..5014341 | - | 1335 | WP_000228013.1 | restriction endonuclease subunit S | - |
| I6K06_RS23685 (5014341) | 5014341..5016779 | - | 2439 | WP_000985465.1 | type I restriction-modification system subunit M | - |
| I6K06_RS23690 (5016819) | 5016819..5017058 | - | 240 | WP_001431807.1 | hypothetical protein | - |
| I6K06_RS23695 (5017340) | 5017340..5017594 | + | 255 | WP_154670580.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | iroN / iroE / iroE / iroD / iroC / aggD / afaC-I | 4985717..5030308 | 44591 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 219 a.a. Molecular weight: 25233.56 Da Isoelectric Point: 6.2145
>T193393 WP_000312833.1 NZ_CP070157:c5012994-5012338 [Escherichia coli]
MAYDYSASLNPQKALIWRIVHRDNIPWILDNGLHCGNSLVQAENWINIGNPELIGKRAGHPVPVGTGGTLHDYVPFYFTP
FSPMLMNIHSGRGGIKQRPNEEIVILVSNLRNVAAHDVPFVFTDSHAYYNWTNYYTSLDSLDQIDWPILQARDFRRDPDD
PAKFERYQAEALIWQHCPISLLDGIICYSEEVRLQLEQWLFQRNLTMSVHTRAGWYFS
MAYDYSASLNPQKALIWRIVHRDNIPWILDNGLHCGNSLVQAENWINIGNPELIGKRAGHPVPVGTGGTLHDYVPFYFTP
FSPMLMNIHSGRGGIKQRPNEEIVILVSNLRNVAAHDVPFVFTDSHAYYNWTNYYTSLDSLDQIDWPILQARDFRRDPDD
PAKFERYQAEALIWQHCPISLLDGIICYSEEVRLQLEQWLFQRNLTMSVHTRAGWYFS
Download Length: 657 bp
>T193393 NZ_CP092911:398189-398530 [Salmonella enterica subsp. enterica]
ATGCAAACCCAATACAACCACCCACACCGGGCGACCCCGTCACAACTATCGCCTGTCGAAATCTGGCAAAAACTGCTGAC
CCATTTACTGGCTAAACATTATGGCCTCGAACTCAGTGACACGCCGTTTAGCGTAGAGAAGGTGATTCAGGAACACATTG
ACGCCGGTATCACGCTGGCTAATGCCGTGAACTTTATTGTAGAGAAATACGAGCTGGTTCGTATCGATCGCAAGGGATTT
AGCTGGCAGGAACAATCACCCTATCTTCGGGCTGTAGACATTCTGCGGGCGCGACAGGCTACGGGTCTGTTGCGACGTCA
ACGCTATCTCGCGGCACACTGA
ATGCAAACCCAATACAACCACCCACACCGGGCGACCCCGTCACAACTATCGCCTGTCGAAATCTGGCAAAAACTGCTGAC
CCATTTACTGGCTAAACATTATGGCCTCGAACTCAGTGACACGCCGTTTAGCGTAGAGAAGGTGATTCAGGAACACATTG
ACGCCGGTATCACGCTGGCTAATGCCGTGAACTTTATTGTAGAGAAATACGAGCTGGTTCGTATCGATCGCAAGGGATTT
AGCTGGCAGGAACAATCACCCTATCTTCGGGCTGTAGACATTCTGCGGGCGCGACAGGCTACGGGTCTGTTGCGACGTCA
ACGCTATCTCGCGGCACACTGA
Antitoxin
Download Length: 356 a.a. Molecular weight: 40672.70 Da Isoelectric Point: 5.6927
>AT193393 WP_000634203.1 NZ_CP070157:c5012341-5011274 [Escherichia coli]
MITYTQGNLLDAPVEALVNTVNTVGVMGKGIALMFKERFPENMKVYALACKQKQVITGKMFITETGELMGPRWIVNFPTK
QHWRADSRMEWIEDGLQDLRRFLIEENVQSIAIPPLGAGNGGLNWPDVRAQIESALGDLQDVDILIYQPTEKYQNVAKST
GVKKLTPARAAIAELVRRYWVLGMECSLLEIQKLAWLLQRAIEQHQQDDILKLRFEAHYYGPYAPNLNHLLNALDGTYLK
AEKRIPDSQPLDVIWFNDQKKEHVNAYLNNEAREWLPALEQVSQLIDGFESPFGLELLATVDWLLSRGECQPTLDSVKEG
LHQWPAGERWASRKLRLFDNNNLQFAINRVMEFHC
MITYTQGNLLDAPVEALVNTVNTVGVMGKGIALMFKERFPENMKVYALACKQKQVITGKMFITETGELMGPRWIVNFPTK
QHWRADSRMEWIEDGLQDLRRFLIEENVQSIAIPPLGAGNGGLNWPDVRAQIESALGDLQDVDILIYQPTEKYQNVAKST
GVKKLTPARAAIAELVRRYWVLGMECSLLEIQKLAWLLQRAIEQHQQDDILKLRFEAHYYGPYAPNLNHLLNALDGTYLK
AEKRIPDSQPLDVIWFNDQKKEHVNAYLNNEAREWLPALEQVSQLIDGFESPFGLELLATVDWLLSRGECQPTLDSVKEG
LHQWPAGERWASRKLRLFDNNNLQFAINRVMEFHC
Download Length: 1068 bp
>AT193393 NZ_CP092911:397804-398145 [Salmonella enterica subsp. enterica]
ATGGACACAAATGAAACACAATCCACGCCAGTATGGGGACTACGGAACGATGTCTTCCCGTCATTTGGCGCTCGGTTAGT
TCAGGAAGGTAATCACCTGCACTATCTGGCTGACCGGGCGGGTATTTATGGTGAATTTACCCCGGCGCAACTACAGACGC
TGGACGTCGTATTTCCAATGTTTATTAAACACATGGAGGCCGCTTTACGCACTGGCGCACTCAACCCGCGAGAGGCCAGA
CGCTTTACGACTGAACTCCGGGGCATAACCTGTGAAGCCGATACGTGCGGATCGTTCGGCTACGTTTATCTTTCGCTTTA
CCCAACCATCGTTAAAAGCTGA
ATGGACACAAATGAAACACAATCCACGCCAGTATGGGGACTACGGAACGATGTCTTCCCGTCATTTGGCGCTCGGTTAGT
TCAGGAAGGTAATCACCTGCACTATCTGGCTGACCGGGCGGGTATTTATGGTGAATTTACCCCGGCGCAACTACAGACGC
TGGACGTCGTATTTCCAATGTTTATTAAACACATGGAGGCCGCTTTACGCACTGGCGCACTCAACCCGCGAGAGGCCAGA
CGCTTTACGACTGAACTCCGGGGCATAACCTGTGAAGCCGATACGTGCGGATCGTTCGGCTACGTTTATCTTTCGCTTTA
CCCAACCATCGTTAAAAGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U9J2A7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U9J2B9 |