Detailed information of TA system TA193392

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-HTH_XRE
• Location: 4907507..4908212
• Replicon: chromosome
• Accession: NZ_CP070157
• Organism: Escherichia coli strain FDAARGOS_1276

Toxin (Protein)

• Gene name: relE
• Uniprot ID: S1F406
• Locus tag: I6K06_RS23195
• Protein ID: WP_000539521.1
• Coordinates: 4907826..4908212 (-)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: I6K06_RS23190
• Protein ID: WP_001280945.1
• Coordinates: 4907507..4907836 (-)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K06_RS23175 (4902664)	4902664..4903575	+	912	Protein_4562	glutathione ABC transporter permease GsiD	-
I6K06_RS23180 (4903753)	4903753..4906101	+	2349	WP_001550886.1	EAL domain-containing protein	-
I6K06_RS23185 (4906109)	4906109..4907437	+	1329	WP_001550887.1	GGDEF domain-containing protein	-
I6K06_RS23190 (4907507)	4907507..4907836	-	330	WP_001280945.1	DNA-binding transcriptional regulator	Antitoxin
I6K06_RS23195 (4907826)	4907826..4908212	-	387	WP_000539521.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
I6K06_RS23200 (4908438)	4908438..4909763	-	1326	WP_000049367.1	30S ribosomal protein S12 methylthiotransferase RimO	-
I6K06_RS23205 (4909976)	4909976..4910359	+	384	WP_000497137.1	biofilm formation regulator BssR	-
I6K06_RS23210 (4910470)	4910470..4911585	+	1116	WP_000555051.1	aldose sugar dehydrogenase YliI	-
I6K06_RS23215 (4911582)	4911582..4912208	-	627	WP_001295292.1	glutathione S-transferase GstB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-124)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-94)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14293.45 Da
• Isoelectric Point: 9.9296

>T193392 WP_000539521.1 NZ_CP070157:c4908212-4907826 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Nucleotide

• Length: 387 bp

>T193392 NZ_CP092911:337040-337324 [Salmonella enterica subsp. enterica]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTTGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTACCACGATGCAAACAAACGGCTTTAG

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 11982.08 Da
• Isoelectric Point: 10.0101

>AT193392 WP_001280945.1 NZ_CP070157:c4907836-4907507 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Nucleotide

• Length: 330 bp

>AT193392 NZ_CP092911:336808-337050 [Salmonella enterica subsp. enterica]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCACTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Structures

Toxin

• AlphaFold DB: A0A829GCT6