Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2635965..2636487 Replicon chromosome
Accession NZ_CP070157
Organism Escherichia coli strain FDAARGOS_1276

Toxin (Protein)


Gene name relE Uniprot ID A0A829L6G8
Locus tag I6K06_RS12635 Protein ID WP_001105433.1
Coordinates 2635965..2636255 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0SC69
Locus tag I6K06_RS12640 Protein ID WP_000212715.1
Coordinates 2636245..2636487 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K06_RS12620 (2631133) 2631133..2632788 + 1656 WP_001550509.1 alpha,alpha-phosphotrehalase -
I6K06_RS12625 (2633182) 2633182..2635320 + 2139 WP_000187798.1 anaerobic ribonucleoside-triphosphate reductase -
I6K06_RS12630 (2635500) 2635500..2635964 + 465 WP_001009182.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
I6K06_RS12635 (2635965) 2635965..2636255 - 291 WP_001105433.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6K06_RS12640 (2636245) 2636245..2636487 - 243 WP_000212715.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
I6K06_RS12645 (2636679) 2636679..2637065 - 387 WP_001232246.1 cytochrome b562 -
I6K06_RS12650 (2637248) 2637248..2638600 - 1353 WP_001162173.1 metalloprotease PmbA -
I6K06_RS12655 (2638694) 2638694..2639245 + 552 WP_000166270.1 ribosome biogenesis factor YjgA -
I6K06_RS12660 (2639395) 2639395..2640768 - 1374 WP_001522402.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11367.23 Da        Isoelectric Point: 10.0238

>T193383 WP_001105433.1 NZ_CP070157:c2636255-2635965 [Escherichia coli]
MNYELAFDPRALKEWQKLGVTVREQFKKKLEDVLKRPRNPSAKLRDLPDCYKIKLRTQGYRLVYQVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Download         Length: 291 bp

>T193383 NZ_CP092907:472967-473083 [Enterococcus faecalis]
ATGTTTTTGTCCGTTGAAGCAGCGCTAGGACTGATGATTGGTTTTGCAACACTTGTTGTGACCATTATCTTCGGTATCTT
AGCGCTTGTCTTAGACAACAAAAATAACCGTTCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9125.56 Da        Isoelectric Point: 5.1369

>AT193383 WP_000212715.1 NZ_CP070157:c2636487-2636245 [Escherichia coli]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Download         Length: 243 bp

>AT193383 NZ_CP092907:c473199-472994 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAGTAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829L6G8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H4B3

References