Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3325626..3326461 Replicon chromosome
Accession NZ_CP070152
Organism Escherichia coli strain FDAARGOS_1285

Toxin (Protein)


Gene name yeeV Uniprot ID A0A2S4A272
Locus tag I6K15_RS16580 Protein ID WP_001094443.1
Coordinates 3326084..3326461 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B7LDN9
Locus tag I6K15_RS16575 Protein ID WP_001285607.1
Coordinates 3325626..3325994 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K15_RS16540 (3321517) 3321517..3322197 + 681 WP_001282919.1 WYL domain-containing protein -
I6K15_RS16545 (3322345) 3322345..3323022 + 678 WP_001097301.1 hypothetical protein -
I6K15_RS16550 (3323052) 3323052..3323261 + 210 WP_032150870.1 DUF905 family protein -
I6K15_RS16555 (3323351) 3323351..3324169 + 819 WP_001175175.1 DUF932 domain-containing protein -
I6K15_RS16560 (3324261) 3324261..3324746 + 486 WP_000213716.1 antirestriction protein -
I6K15_RS16565 (3324762) 3324762..3325238 + 477 WP_204628319.1 RadC family protein -
I6K15_RS16570 (3325325) 3325325..3325546 + 222 WP_000692350.1 DUF987 domain-containing protein -
I6K15_RS16575 (3325626) 3325626..3325994 + 369 WP_001285607.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
I6K15_RS16580 (3326084) 3326084..3326461 + 378 WP_001094443.1 TA system toxin CbtA family protein Toxin
I6K15_RS16585 (3326458) 3326458..3326946 + 489 WP_000761685.1 DUF5983 family protein -
I6K15_RS16590 (3326966) 3326966..3327163 + 198 WP_001327226.1 DUF957 domain-containing protein -
I6K15_RS16595 (3327248) 3327248..3327391 + 144 Protein_3140 hypothetical protein -
I6K15_RS16600 (3327858) 3327858..3328639 + 782 Protein_3141 integrase arm-type DNA-binding domain-containing protein -
I6K15_RS24935 (3328759) 3328759..3328959 + 201 Protein_3142 transposase -
I6K15_RS16610 (3329157) 3329157..3330050 - 894 WP_032172247.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3328759..3328863 104


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14058.97 Da        Isoelectric Point: 7.3523

>T193352 WP_001094443.1 NZ_CP070152:3326084-3326461 [Escherichia coli]
MNTLPDTHVREASHCQSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T193352 NZ_CP092888:c1045121-1044837 [Bifidobacterium sp. FKU]
ATGAGCACCGAATTCACCGACTACGACACCAGCGAATACCTCGAAAACGAACAGGACATCATCGCCTACCTCAACGCCAT
AGCCGAATATGACGACCCCGCACTCATGCAGGCCGCGCTCGGCAACGTCGCCAAGGCCCGGGGCATGACCCAGATCGCCA
AGGACGCGGGCGTGGGGCGCGAAAGCCTCTACAAGAGCCTCAGCAAGGACGGCAACCCCAGCTTCCAGACCATCGCCAAG
GTAATCCACGCCCTCGGCGGACGCCTCACCATCCAAGCCGCCTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13689.53 Da        Isoelectric Point: 6.4669

>AT193352 WP_001285607.1 NZ_CP070152:3325626-3325994 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKRLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT193352 NZ_CP092888:c1045420-1045118 [Bifidobacterium sp. FKU]
ATCAAGCAATCCGCCGAATACCGCAAGTGGTTCAAGAAACTCAGGGACCACAAAGCGAAGGCCGCCATCCAAGCCCGGCT
CGATGCCTGCAAGCTCGCAGGCAGGCCATTCGGCGACATCAAACCCGTGGGAGGCCCGGTCAGCGAGATGCGGTTCCACA
CCGGGGCCGGATACCGCGTCTACTTCGCCATGCAGGGCAACGTGCTCATGCTGCTGCTCGCAGGCGGCGACAAAAGCACC
CAGCAGACCGACATCAGACAAGCCCACGACATCCTCAACGACTACAAGGAACAACGACAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S4A272

Antitoxin

Source ID Structure
AlphaFold DB A0A1M0JLU8

References