Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 3223541..3224136 Replicon chromosome
Accession NZ_CP070152
Organism Escherichia coli strain FDAARGOS_1285

Toxin (Protein)


Gene name chpB Uniprot ID V0SXT4
Locus tag I6K15_RS16060 Protein ID WP_000239581.1
Coordinates 3223786..3224136 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag I6K15_RS16055 Protein ID WP_001223213.1
Coordinates 3223541..3223792 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K15_RS16045 (3219206) 3219206..3222985 + 3780 WP_022646473.1 autotransporter assembly complex protein TamB -
I6K15_RS16050 (3222988) 3222988..3223329 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
I6K15_RS16055 (3223541) 3223541..3223792 + 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
I6K15_RS16060 (3223786) 3223786..3224136 + 351 WP_000239581.1 endoribonuclease toxin ChpB Toxin
I6K15_RS16065 (3224215) 3224215..3224745 - 531 WP_000055075.1 inorganic diphosphatase -
I6K15_RS16070 (3225055) 3225055..3226011 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
I6K15_RS16075 (3226144) 3226144..3227646 + 1503 WP_022646474.1 sugar ABC transporter ATP-binding protein -
I6K15_RS16080 (3227657) 3227657..3228681 + 1025 Protein_3036 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12453.41 Da        Isoelectric Point: 6.2206

>T193351 WP_000239581.1 NZ_CP070152:3223786-3224136 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

>T193351 NZ_CP092888:c15360-15070 [Bifidobacterium sp. FKU]
ATGAGCGGCATCCAGTACACGGTCAAGACCACGTCCAGATTCAGGAAGGACTTCAAACTCGCCAGACGACGCGGACTGGA
CGCCGGCCTTTTCAAACAGGTTGTATCCATTCTGTCCGAGGGCGGCACACTGCCCGACCGATATCATGACCATGCGCTTA
CAGGCAATATGACCGGCTTCAGGGAGTGCCATATCACACCAGACCTGCTGTTGGTCTATCTCATAGAGAAGGACGTGCTG
GTGCTCACTCTGACCCGAACGGGCACCCATAGTGATCTTTTCGGAAAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT193351 WP_001223213.1 NZ_CP070152:3223541-3223792 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT193351 NZ_CP092888:c15635-15357 [Bifidobacterium sp. FKU]
ATGAGCGGAACGACAACCACCGTTAACGTCCGAATGAACGCTGAGCTGAAAAAACAAGCCGAGGAACTGTTCGAGGAGCT
GGGCATGAACCTGACCACCGCAGTCAACATATTCATCCGCCAATCCCTGCGACAGGGCGGCATACCGTTCAACGTCTCGT
TGGATGAGCCGAACAGGGAGACCGTCTCCGCCATGTTGGAGGCGAAGCGAATCGCAAGGGACGGGAACGTGAAGGGCTAC
CGGGACCTGAACGCCTTGTTCAAGGACTTGGACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SXT4

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References