Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2424447..2425059 Replicon chromosome
Accession NZ_CP070152
Organism Escherichia coli strain FDAARGOS_1285

Toxin (Protein)


Gene name hicA Uniprot ID U9YXE2
Locus tag I6K15_RS12380 Protein ID WP_000833473.1
Coordinates 2424874..2425059 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0A1AGA0
Locus tag I6K15_RS12375 Protein ID WP_022646255.1
Coordinates 2424447..2424857 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K15_RS12360 (2419904) 2419904..2420719 - 816 WP_022646253.1 AraC family transcriptional regulator -
I6K15_RS12365 (2420945) 2420945..2422345 + 1401 WP_001600688.1 MFS transporter -
I6K15_RS12370 (2422356) 2422356..2424335 + 1980 WP_022646254.1 glycoside hydrolase family 127 protein -
I6K15_RS12375 (2424447) 2424447..2424857 - 411 WP_022646255.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
I6K15_RS12380 (2424874) 2424874..2425059 - 186 WP_000833473.1 type II toxin-antitoxin system HicA family toxin Toxin
I6K15_RS12385 (2425532) 2425532..2426611 + 1080 WP_000061477.1 type I restriction enzyme HsdR N-terminal domain-containing protein -
I6K15_RS12390 (2426652) 2426652..2428190 - 1539 WP_000183976.1 aldehyde dehydrogenase AldB -
I6K15_RS12395 (2428298) 2428298..2429593 - 1296 WP_000985736.1 Fic family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6800.89 Da        Isoelectric Point: 11.7053

>T193349 WP_000833473.1 NZ_CP070152:c2425059-2424874 [Escherichia coli]
VKSADVIAILKQHGWEHIRTRGSHHQFRHPVHPGLVTVPHPKKDIKPGTLAQIGRQAGLTF

Download         Length: 186 bp

>T193349 NZ_CP092862:c177919-177605 [Salmonella enterica]
ATGCAGTTTACTGTATACCGCAATACAGGAAAAATCGTGGCTTACCCTTTGTTGCTTGATGTCACGAGCGATATTATAGG
GCAGTTGAACCGGCGGGTTGTGATCCCGCTGCTGCCTGTTGAAAAATATCCGGGCGCTGCCCGCCCGGAGCGAATGATCC
CCATTATCAGACTGACGGACGGCAGGGAATACGCCGTAATGACTCACGAACTGGCGAGTATACCCATTCGTGCCCTGGGG
GCTGAATTCTGCGATGCGGCTCAGTATCGTACACAGATAAAAGCTGCAATCGATTTTCTCTTTGACGGAATTTAA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 15214.08 Da        Isoelectric Point: 4.4482

>AT193349 WP_022646255.1 NZ_CP070152:c2424857-2424447 [Escherichia coli]
MFYPAYIHSDPDGSASGFFPDVPGCYFAGDTLDNAFQDARSALAAHFETLCEMDEELPLPGSVETHLVQRAQDFIGGQWL
LVDINMNQFEGRAERINITMPKRLLNKIDTYVRNNPDYANRSAFLAEAARRVLPGV

Download         Length: 411 bp

>AT193349 NZ_CP092862:c178158-177922 [Salmonella enterica]
GTGACAGCAAAACAACGCAATACTCAGAGCGTTACAGTGACTGTGGAACGGGGATTATTAAGCCTGGCGCGTGAGGCCGG
CATTAACCTCAGCGCCACCTTAACCGCCGCCTTGGATGCGGAGCTGCGTGAGCATGCCACGAGAAAATGGCAGGAAAAGA
ACACGGAAGCCCTTGAGGCATTAAATCGTTTTCATGATGAGCATGGTTGCTTCAGCGATGAATACAGGACATTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YXE2

Antitoxin

Source ID Structure
AlphaFold DB A0A0A1AGA0

References