Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1736457..1737289 Replicon chromosome
Accession NZ_CP070152
Organism Escherichia coli strain FDAARGOS_1285

Toxin (Protein)


Gene name yeeV Uniprot ID S1PD64
Locus tag I6K15_RS09085 Protein ID WP_000854753.1
Coordinates 1736915..1737289 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NQ68
Locus tag I6K15_RS09080 Protein ID WP_001540478.1
Coordinates 1736457..1736825 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K15_RS09045 (1732290) 1732290..1732970 + 681 WP_001282919.1 WYL domain-containing protein -
I6K15_RS09050 (1733118) 1733118..1733795 + 678 WP_001097301.1 hypothetical protein -
I6K15_RS09055 (1733801) 1733801..1734034 + 234 WP_001278283.1 DUF905 family protein -
I6K15_RS09060 (1734124) 1734124..1734942 + 819 WP_001234382.1 DUF932 domain-containing protein -
I6K15_RS09065 (1735033) 1735033..1735518 + 486 WP_023909076.1 antirestriction protein -
I6K15_RS09070 (1735534) 1735534..1736010 + 477 WP_061092719.1 RadC family protein -
I6K15_RS09075 (1736073) 1736073..1736294 + 222 WP_000692311.1 DUF987 domain-containing protein -
I6K15_RS09080 (1736457) 1736457..1736825 + 369 WP_001540478.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
I6K15_RS09085 (1736915) 1736915..1737289 + 375 WP_000854753.1 TA system toxin CbtA family protein Toxin
I6K15_RS09090 (1737286) 1737286..1737774 + 489 WP_000777545.1 DUF5983 family protein -
I6K15_RS09095 (1737786) 1737786..1737983 + 198 WP_000839281.1 DUF957 domain-containing protein -
I6K15_RS09100 (1738080) 1738080..1738649 + 570 WP_001290252.1 DUF4942 domain-containing protein -
I6K15_RS09105 (1738992) 1738992..1739162 + 171 Protein_1672 IS110 family transposase -
I6K15_RS09110 (1739973) 1739973..1740956 + 984 WP_001355482.1 KpsF/GutQ family sugar-phosphate isomerase -
I6K15_RS09115 (1741028) 1741028..1742176 + 1149 WP_000905925.1 capsule polysaccharide transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - sfaX / kpsF 1698142..1740956 42814
- flank IS/Tn - - 1739007..1739162 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14005.00 Da        Isoelectric Point: 8.2905

>T193347 WP_000854753.1 NZ_CP070152:1736915-1737289 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

>T193347 NZ_CP092862:c132869-132453 [Salmonella enterica]
ATGCTCGATACCTGCATCTGCTCATTCATCATGCGTGAGCAGCCCGCCGCAGTGATCAAACGTCTGGAGCAGGCGGTGCT
GCGTAACCACCGCATTGTCGTGTCGGCTATCACCTATGCGGAGATGCGTTTCGGCGCCACCGGCCCGAAAGCCTCACCGC
GTCATATTGCGCTGGTTGACGCGTTCTGCGCCCGCCTCGATGCCATTCTGCCCTGGGACCGCGCTGCAGTGGACGCCACC
ACGGAGATTAAAGTGGCGCTGCGCCAGACTGGCACGCCAATAGGCCCGAACGACACGGCGATCGCCGGGCATGCGATGGC
GGTGGGGGCCATTCTGGTGACGAATAATACGCGGGAGTTTGAGCGGGTGCCGGAGTTGAGTCTGGAAGACTGGGTAAAAT
ATGCCGGTGCATTATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13652.53 Da        Isoelectric Point: 7.8398

>AT193347 WP_001540478.1 NZ_CP070152:1736457-1736825 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT193347 NZ_CP092862:c133123-132893 [Salmonella enterica]
ATGCGAACTGTATCCATTTTTAAAAATGGCAATAACCGTGCCATTCGCTTACCCCGCGATCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATATTGCGTCCTGTCCGGCCGACCTGGGGCTCGTTTGCAGAGCTGG
AAAAAGCCGATGCGGACTTTATGGTGGAGCGTGAGGACGTTGTCAGCGACGAAGGACGATTTGACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LVU0

Antitoxin

Source ID Structure
AlphaFold DB S1NQ68

References