Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/RelE-RHH |
| Location | 10569..11116 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP070151 | ||
| Organism | Escherichia coli strain FDAARGOS_1285 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | - |
| Locus tag | I6K15_RS00045 | Protein ID | WP_244448944.1 |
| Coordinates | 10569..10847 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | E1QMW3 |
| Locus tag | I6K15_RS00050 | Protein ID | WP_000079941.1 |
| Coordinates | 10847..11116 (-) | Length | 90 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I6K15_RS00025 (6241) | 6241..6957 | + | 717 | Protein_4 | Tn3 family transposase | - |
| I6K15_RS24730 (6990) | 6990..7124 | - | 135 | Protein_5 | DUF6404 family protein | - |
| I6K15_RS00030 (7253) | 7253..7588 | + | 336 | WP_001080729.1 | colicin 1A immunity protein | - |
| I6K15_RS24735 (7610) | 7610..7924 | - | 315 | WP_250151204.1 | colicin-like pore-forming protein | - |
| I6K15_RS00035 (7921) | 7921..9489 | - | 1569 | WP_250151205.1 | colicin Ia central receptor-binding domain-containing protein | - |
| I6K15_RS00040 (9675) | 9675..10523 | - | 849 | WP_001057989.1 | 3'-5' exonuclease | - |
| I6K15_RS00045 (10569) | 10569..10847 | - | 279 | WP_244448944.1 | type II toxin-antitoxin system toxin YacB | Toxin |
| I6K15_RS00050 (10847) | 10847..11116 | - | 270 | WP_000079941.1 | type II toxin-antitoxin system antitoxin YacA | Antitoxin |
| I6K15_RS00055 (12031) | 12031..12888 | - | 858 | WP_001514234.1 | incFII family plasmid replication initiator RepA | - |
| I6K15_RS00060 (12881) | 12881..12955 | - | 75 | WP_001365705.1 | RepA leader peptide Tap | - |
| I6K15_RS00065 (13180) | 13180..13440 | - | 261 | WP_204628296.1 | replication regulatory protein RepA | - |
| I6K15_RS00070 (13680) | 13680..14270 | - | 591 | WP_000766816.1 | DUF2726 domain-containing protein | - |
| I6K15_RS00075 (14309) | 14309..14518 | - | 210 | WP_001514235.1 | hemolysin expression modulator Hha | - |
| I6K15_RS00080 (14564) | 14564..15025 | - | 462 | WP_001514236.1 | thermonuclease family protein | - |
| I6K15_RS00085 (15270) | 15270..15482 | - | 213 | WP_001371875.1 | ANR family transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | blaTEM-6 / sitABCD | iutA / iucD / iucC / iucB / iucA / iroB / iroC / iroD / iroE / iroN | 1..136864 | 136864 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10792.40 Da Isoelectric Point: 8.4615
>T193336 WP_244448944.1 NZ_CP070151:c10847-10569 [Escherichia coli]
MEIFWTMLTSQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP
MEIFWTMLTSQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP
Download Length: 279 bp
>T193336 NZ_CP092861:885349-885762 [Salmonella enterica]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTAATGCCCTGGCCGCTGAGTTATACTCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTTATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTGA
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTAATGCCCTGGCCGCTGAGTTATACTCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTTATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTGA
Antitoxin
Download Length: 90 a.a. Molecular weight: 10252.58 Da Isoelectric Point: 7.2057
>AT193336 WP_000079941.1 NZ_CP070151:c11116-10847 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK
Download Length: 270 bp
>AT193336 NZ_CP092861:885102-885368 [Salmonella enterica]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|