Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2773261..2774092 Replicon chromosome
Accession NZ_CP070148
Organism Escherichia coli strain FDAARGOS_1297

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag I6K27_RS13365 Protein ID WP_000854814.1
Coordinates 2773718..2774092 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1PWQ3
Locus tag I6K27_RS13360 Protein ID WP_001285586.1
Coordinates 2773261..2773629 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K27_RS13325 (2768319) 2768319..2769389 + 1071 WP_000102631.1 patatin-like phospholipase family protein -
I6K27_RS13330 (2769525) 2769525..2770202 + 678 WP_001362823.1 hypothetical protein -
I6K27_RS13335 (2770218) 2770218..2770628 + 411 WP_000846704.1 hypothetical protein -
I6K27_RS13340 (2770849) 2770849..2771670 + 822 WP_001234570.1 DUF932 domain-containing protein -
I6K27_RS13345 (2771933) 2771933..2772406 + 474 WP_000855071.1 antirestriction protein -
I6K27_RS13350 (2772421) 2772421..2772897 + 477 WP_001298074.1 RadC family protein -
I6K27_RS13355 (2772966) 2772966..2773187 + 222 WP_000692323.1 DUF987 domain-containing protein -
I6K27_RS13360 (2773261) 2773261..2773629 + 369 WP_001285586.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
I6K27_RS13365 (2773718) 2773718..2774092 + 375 WP_000854814.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
I6K27_RS13370 (2774089) 2774089..2774283 + 195 WP_000988601.1 DUF5983 family protein -
I6K27_RS13375 (2774329) 2774329..2774409 + 81 Protein_2649 hypothetical protein -
I6K27_RS25315 (2774698) 2774698..2774778 - 81 WP_023441679.1 hypothetical protein -
I6K27_RS25320 (2774757) 2774757..2775080 + 324 WP_223216378.1 EutP/PduV family microcompartment system protein -
I6K27_RS13390 (2775181) 2775181..2775510 - 330 WP_000450409.1 DUF496 family protein -
I6K27_RS13395 (2775682) 2775682..2776740 - 1059 WP_001200890.1 FUSC family protein -
I6K27_RS13400 (2776938) 2776938..2777411 - 474 WP_001105376.1 DNA gyrase inhibitor SbmC -
I6K27_RS13405 (2777530) 2777530..2778695 - 1166 Protein_2655 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T193329 WP_000854814.1 NZ_CP070148:2773718-2774092 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T193329 NZ_CP092860:854594-855001 [Citrobacter braakii]
GTGGTCCAGTGGCAATCTGATTTACGCGTTTCATGGCGCGCGCAATGGCTTTCGCTGCTCATTCATGGGCTGGTCGCGGT
ATTTATTTTATTGATGCCCTGGCCATTGAGCTACACCCCATTATGGCTGGTTCTGCTCTCTCTGGTGGTGTTCGATAGCG
TCCGTAGCCAGCGCCGAATCAATGCCTGTCAGGGCGAGATTCGGCTGTTGATGGACGGTCGTCTGCGCTGGCAAGGGCAA
GAGTGGACTATTGCTAGCGCACCCTGGATGGTCAAAACAGGCATGATGCTGCGTTTACGTTCCGATGCCGGAAAACGTCA
GCATTTGTGGCTGGCGGCAGACAGTATGGATGACGCGGAGTGGCGGGATTTGCGGCGGTTAATACTGCAACAGGCGAAGC
AGGGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13563.41 Da        Isoelectric Point: 5.0468

>AT193329 WP_001285586.1 NZ_CP070148:2773261-2773629 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT193329 NZ_CP092860:854347-854613 [Citrobacter braakii]
ATGGATATTAACAACAAAGCACGTATTCATTGGGCATGCCGTCGCGGTATGCGTGAGCTGGACATCTCGATCATGCCGTT
TTTCGAACATGAATATGACAGCTTAAGTGACGAAGAAAAACGTATCTTTATCCGTCTGCTAGAATGTGATGATCCAGACT
TATTTAACTGGTTGATGAATCATGGGAAACCGGCTGATGCTCAGCTAGAGCAGATGGTGCGACTTATCCAGACACGGAAT
CGGGAACGTGGTCCAGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB S1PWQ3

References