Detailed information of TA system TA193314

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 1684043..1684841
• Replicon: chromosome
• Accession: NZ_CP070148
• Organism: Escherichia coli strain FDAARGOS_1297

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: Q1RDD2
• Locus tag: I6K27_RS07900
• Protein ID: WP_001094434.1
• Coordinates: 1684467..1684841 (+)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: I6K27_RS07895
• Protein ID: WP_001552747.1
• Coordinates: 1684043..1684420 (+)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K27_RS07865 (1680921)	1680921..1681742	+	822	WP_001234585.1	DUF932 domain-containing protein	-
I6K27_RS07870 (1681742)	1681742..1681987	+	246	WP_001164966.1	hypothetical protein	-
I6K27_RS07875 (1682081)	1682081..1682554	+	474	WP_001542276.1	antirestriction protein	-
I6K27_RS07880 (1682570)	1682570..1683046	+	477	WP_001186727.1	RadC family protein	-
I6K27_RS07885 (1683109)	1683109..1683330	+	222	WP_000692315.1	DUF987 domain-containing protein	-
I6K27_RS07890 (1683349)	1683349..1683993	+	645	WP_000086759.1	hypothetical protein	-
I6K27_RS07895 (1684043)	1684043..1684420	+	378	WP_001552747.1	type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA	Antitoxin
I6K27_RS07900 (1684467)	1684467..1684841	+	375	WP_001094434.1	TA system toxin CbtA family protein	Toxin
I6K27_RS07905 (1684838)	1684838..1685329	+	492	WP_000976859.1	DUF5983 family protein	-
I6K27_RS07910 (1685341)	1685341..1685538	+	198	WP_000839257.1	DUF957 domain-containing protein	-
I6K27_RS07915 (1685631)	1685631..1686473	+	843	WP_001280460.1	DUF4942 domain-containing protein	-
I6K27_RS07925 (1686944)	1686944..1687882	+	939	WP_000351298.1	glyoxylate/hydroxypyruvate reductase GhrA	-
I6K27_RS07930 (1687937)	1687937..1688674	+	738	WP_000283664.1	zinc-binding phosphatase	-
I6K27_RS07935 (1688698)	1688698..1689252	+	555	WP_001001909.1	molecular chaperone YcdY	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 13921.82 Da
• Isoelectric Point: 6.8517

>T193314 WP_001094434.1 NZ_CP070148:1684467-1684841 [Escherichia coli]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAK

Nucleotide

• Length: 375 bp

>T193314 NZ_CP092852:c571913-571617 [Burkholderia contaminans]
ATGGAAAAGAGAACGCCTCATTGCAAGCTGCCTCGCGTCAAGGCACTCGTCGAAACCGGCCAGGTCCGGCTAACGGCGAG
TGCGGTACTCGGCGCCCGGCTATTGGGTTTCACGGAACGGGAGGCGCTCGATGTCGTGCTGTCGCTGACCGATCTCGACT
TCCACAAGAGCATGACGACGTACGCCGACCACACGATCTGGCAGGACGTCTACCGACCTTTCACGGTGCGTGGCGACGTG
TACCTGAAACTGACGGTGATCGACGATGTGCTGATCGTGTCTTTCAAGGAGCGATGA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 13757.63 Da
• Isoelectric Point: 6.3127

>AT193314 WP_001552747.1 NZ_CP070148:1684043-1684420 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRTGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPAITV

Nucleotide

• Length: 378 bp

>AT193314 NZ_CP092852:c571614-571213 [Burkholderia contaminans]
ATGAAGTGCCCTGCATGCGGTGCCGCCAGGCTGGTCCGCGACACGCGAGACATCCCTTATACCTACAAGGGCCGGTCGAC
TGTCGTTCGCGACATCACCGGCGATTTCTGCCCGGCCTGCGGGGAATCGGTGCTGGATCTCGACGAGGCGACCCGTCTCG
GCGAAGCGATCACCGAATTCAACAAGCAGGTGAACGCCACCATCGTCGACCCGAAGTACATCGCGAAGGTGCGCAAGAAG
CTGAAGCTGGATCAGCGCGAGGCAGCCGAGCTCTTCGGCGGTGGAGTCAACGCGTTCTCCCGTTACGAAACGGGCAAGAC
GAATCCGCCGCTTGCCCTCGTGAAATTGCTGAAGCTCCTGGATCGTCACCCCGATCTGCTCGCCGAAGTTCGAGCGGCAT
AG

Structures

Toxin

• AlphaFold DB: Q1RDD2