Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 421162..421997 Replicon chromosome
Accession NZ_CP070148
Organism Escherichia coli strain FDAARGOS_1297

Toxin (Protein)


Gene name yeeV Uniprot ID Q1R2L4
Locus tag I6K27_RS01955 Protein ID WP_001094426.1
Coordinates 421620..421997 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID Q1R2L5
Locus tag I6K27_RS01950 Protein ID WP_001285575.1
Coordinates 421162..421530 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K27_RS01915 (417055) 417055..417735 + 681 WP_001282919.1 WYL domain-containing protein -
I6K27_RS01920 (417883) 417883..418560 + 678 WP_001097301.1 hypothetical protein -
I6K27_RS01925 (418566) 418566..418799 + 234 WP_001278290.1 DUF905 family protein -
I6K27_RS01930 (418889) 418889..419707 + 819 WP_001175160.1 DUF932 domain-containing protein -
I6K27_RS01935 (419798) 419798..420283 + 486 WP_000213697.1 antirestriction protein -
I6K27_RS01940 (420298) 420298..420774 + 477 WP_001298074.1 RadC family protein -
I6K27_RS01945 (420861) 420861..421082 + 222 WP_000692350.1 DUF987 domain-containing protein -
I6K27_RS01950 (421162) 421162..421530 + 369 WP_001285575.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
I6K27_RS01955 (421620) 421620..421997 + 378 WP_001094426.1 TA system toxin CbtA family protein Toxin
I6K27_RS01960 (421994) 421994..422482 + 489 WP_000761683.1 DUF5983 family protein -
I6K27_RS01965 (422494) 422494..422691 + 198 WP_000839272.1 DUF957 domain-containing protein -
I6K27_RS01970 (422776) 422776..422925 + 150 Protein_390 hypothetical protein -
I6K27_RS01975 (424153) 424153..425916 + 1764 WP_001555776.1 hypothetical protein -
I6K27_RS01980 (426315) 426315..426494 - 180 Protein_392 peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimB / fimE / fimA / fimI / fimC 408459..436053 27594


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14072.99 Da        Isoelectric Point: 7.3523

>T193308 WP_001094426.1 NZ_CP070148:421620-421997 [Escherichia coli]
MNTLPDTHIREASHCQSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T193308 NZ_CP092848:4615397-4615909 [Methylobacterium organophilum]
ATGCCTGAGCCGGGAAGCCGGCTCGTCCTCTGGCGCGCCTACGTTCCCCGCTGGGCGCACGATCCTCTGTCCGGGGCCGG
GGCGGCTCGCTTCGGCGGACGCTGGAACAGGATCGGGCAGCCCTGCCTCTACGCAGCCCGCGAGTTGTCGACGGCCTGGG
CGGAATACAATCAGGGTTTCGTGCAGCATCCTGCCACCATCGCGCAGCTCATCCTCAAAGGGGCTCGTCTGGCCGATCTG
ACCGCGCCGGACGGCCTGCGGGGGCTCGGCCTGCCCGACGACCTGCACCGGGCGGAGTGGCGCGCGGATCTCGACGCGGG
ACGGCTGCCAGAGACGCATCGCGCGGCCGAACGGCTCCTTGAGGCGGGTTTCCACGGCCTGATCCATCCCTCCTTCATGT
CCCGCGGCGGCACCGGCATCGCCCTGTGGCGCTGGAATGGCGAGGAGGGTCCCCGCCTGTCCGTCATCGACCCGGAGGGC
CGCCTCCCGAAGACCGACGCGCCCTGGTTGTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13709.52 Da        Isoelectric Point: 6.6258

>AT193308 WP_001285575.1 NZ_CP070148:421162-421530 [Escherichia coli]
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKRLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT193308 NZ_CP092848:4615033-4615404 [Methylobacterium organophilum]
ATGCCGATGAGCGCCCTGCCCTCCGTCGCCACCCTCTTCCGCGAGGCCGATGCGCCCTATCTTTCGCCGCGCCGGGTGGC
GGAGGGGCTCGGTCTCACGCTGACCGAGCTCGCGCGGCTCGCCGGCATCTCGCGCAACACGCTGACGGCTTCCCGCGGAA
CGCGCTCCGTCGAGGGAGCCCTGAGCCCCATCGTGCGCATCATCGCCATGGCCGCGGAGATGACCGGCGACGAGATGCGG
GCGGCGATCTGGTTCAAGCACCAGCCGATCCCGGGCTGGGCCGGCAAGACGGCCTACGACCTCGTGCGCGAGCACAAGGC
GGATAAGGTCATCGCCTATCTCGAAGCGGTGCGCGCCGGCGTCTATGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454ABD6

Antitoxin

Source ID Structure
AlphaFold DB A0A454ABF5

References