Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3558489..3559146 Replicon chromosome
Accession NZ_CP070144
Organism Klebsiella oxytoca strain FDAARGOS_1331

Toxin (Protein)


Gene name cptA Uniprot ID A0A181X6I0
Locus tag I6K61_RS16640 Protein ID WP_004105559.1
Coordinates 3558736..3559146 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A285B945
Locus tag I6K61_RS16635 Protein ID WP_004105561.1
Coordinates 3558489..3558755 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K61_RS16610 3553669..3555102 - 1434 WP_049128113.1 6-phospho-beta-glucosidase -
I6K61_RS16615 3555223..3555951 - 729 WP_064352017.1 MurR/RpiR family transcriptional regulator -
I6K61_RS16620 3556002..3556313 + 312 WP_004105571.1 N(4)-acetylcytidine aminohydrolase -
I6K61_RS16625 3556475..3557134 + 660 WP_004105569.1 hemolysin III family protein -
I6K61_RS16630 3557262..3558245 - 984 WP_004115279.1 tRNA-modifying protein YgfZ -
I6K61_RS16635 3558489..3558755 + 267 WP_004105561.1 FAD assembly factor SdhE Antitoxin
I6K61_RS16640 3558736..3559146 + 411 WP_004105559.1 protein YgfX Toxin
I6K61_RS16645 3559155..3559676 - 522 WP_004105557.1 flavodoxin FldB -
I6K61_RS16650 3559798..3560694 + 897 WP_004105555.1 site-specific tyrosine recombinase XerD -
I6K61_RS16655 3560717..3561430 + 714 WP_024274699.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
I6K61_RS16660 3561436..3563169 + 1734 WP_204753011.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16061.83 Da        Isoelectric Point: 10.9455

>T193298 WP_004105559.1 NZ_CP070144:3558736-3559146 [Klebsiella oxytoca]
VVLWQSDLRISWRAQWFSLLMHGVVAALVLVLPWPLSYTPLWLILLSLVVFDCVRSQRRIHARQGEIKLLIDSRLRWQKA
EWDIVGTPWVINSGMLLRLRNTENQRTQHLWVAADSMDAGEWRDLRRLVLQKPTQD

Download         Length: 411 bp

>T193298 NZ_CP092844:1494262-1494540 [Burkholderia ambifaria]
ATGATCCAGTCGTTCAAATGCAAAGACACTCGGCAGTTGTTCGAAACCGGACGTTGCCGACAATTCGCCAATATTGCCGA
TGTGGCCATGCGTCGACTCACGCAGCTTGACAACGCGGTGACGCTGGATGCATTGAAATCTCCGCCCGGCAACCGATTTG
AGGCATTGAAAGGTGACCGCCTGGGCCAGTACAGCATCCGAATCAATGGTCAATGGCGTGTGTGCTTTACATGGGGCGAT
GACGGGCCAGCCGATGTTGAAATCGCCGACTATCACTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1498

>AT193298 WP_004105561.1 NZ_CP070144:3558489-3558755 [Klebsiella oxytoca]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDDDKRLFIRLLENDDPDLFNWLMNHGEPADAELQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT193298 NZ_CP092844:1494553-1494867 [Burkholderia ambifaria]
ATGAGCCGGTTCAAAAACGGCATGCGCCCGGTCCATCCGGGCGAAATTCTTCGTGAGGACTACCTCATCCCGCTCGACAT
GAGCGCGAACGCGCTGGCAGGCGCACTTGGCGTCACGGCCGGCCGCATCAACGATATCGTCCGTGAGCGGCGCGGCATCA
CGGCCGATACGGCGCTGCGCCTTGCCCGCTACTTTGGCGGCGATCCGCAGACGTGGCTGAACCTGCAAGCCACGTATGAT
CTGAAAATCGCCGAGCGCGACCACGGCCGCGAGATCCAGAAGCGCATCGAGCCTCGAGAATTCGCCCACGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A181X6I0

Antitoxin

Source ID Structure
AlphaFold DB A0A285B945

References