Detailed information of TA system TA193285

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 3544284..3545098
• Replicon: chromosome
• Accession: NZ_CP070134
• Organism: Escherichia coli strain FDAARGOS_1281

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: I6K11_RS18000
• Protein ID: WP_001054376.1
• Coordinates: 3544841..3545098 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: U9Z4B8
• Locus tag: I6K11_RS17995
• Protein ID: WP_001309181.1
• Coordinates: 3544284..3544829 (-)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K11_RS17965 (3539975)	3539975..3541288	-	1314	WP_000460843.1	PTS sugar transporter subunit IIC SgcC	-
I6K11_RS17970 (3541300)	3541300..3541578	-	279	WP_000722973.1	PTS sugar transporter subunit IIB SgcB	-
I6K11_RS17975 (3541575)	3541575..3542696	-	1122	WP_000010829.1	M42 family metallopeptidase	-
I6K11_RS17980 (3542941)	3542941..3543057	-	117	Protein_3348	VOC family protein	-
I6K11_RS17985 (3543095)	3543095..3543313	-	219	Protein_3349	hypothetical protein	-
I6K11_RS17990 (3543482)	3543482..3544228	-	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
I6K11_RS17995 (3544284)	3544284..3544829	-	546	WP_001309181.1	N-acetyltransferase	Antitoxin
I6K11_RS18000 (3544841)	3544841..3545098	-	258	WP_001054376.1	YjhX family toxin	Toxin
I6K11_RS27715 (3545589)	3545589..3545720	-	132	WP_001309182.1	hypothetical protein	-
I6K11_RS18010 (3545836)	3545836..3547076	+	1241	Protein_3354	helicase YjhR	-
I6K11_RS27720 (3547344)	3547344..3547549	-	206	Protein_3355	HNH endonuclease	-
I6K11_RS18015 (3547659)	3547659..3548639	-	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
I6K11_RS18020 (3548704)	3548704..3549810	-	1107	WP_001309184.1	N-acetylneuraminate epimerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T193285 WP_001054376.1 NZ_CP070134:c3545098-3544841 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T193285 NZ_CP092831:1511131-1511481 [Paenibacillus peoriae]
TTGATCGTAAAGCGCGGCGACGTTTTTTTTGCAGACCTTTCACCCGTAGTCGGTTCCGAGCAAGGTGGCGTCAGACCTGT
GCTGATCATTCAAAATGATATCGGCAATCGGTTTAGTCCTACCGTGATCGTGGCAGCTATCACCGCTCAGATTCAGAAGG
CAAAGCTGCCTACACACGTGGAAATCGACGCGGCGACGCATGGCTTTGATCGTGATTCTGTTGTTCTTCTGGAGCAAATT
CGGACGATCGACAAGCAAAGGCTTACCGACAAAATCACCCACTTAGATGAAGAAACTATGCGCAAAGTGAGCGATTCGCT
ACAAATCAGTCTCGGTTTGATTGATTTTTAG

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19956.90 Da
• Isoelectric Point: 6.3277

>AT193285 WP_001309181.1 NZ_CP070134:c3544829-3544284 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT193285 NZ_CP092831:1510843-1511124 [Paenibacillus peoriae]
TTGGCCAATTTGCAGAACACCAAAAGAATAATGATCAGTTTGCCAGATCATCTCTTACAGGAAGTGGACGGGATCGTAGC
TATGGAAAATTCCAACCGCAGTGAATTTATCAGGCAGGCCATGAAGCTGTATGTAGGCGAACGTAAAAAACGTTACATTC
GTGAAGCTATGCAGCGTGGATACATGGAAATGGCTAAAATTAACTTGACCATGGCATCCGAAGCCTTTCACGCGGAGGAA
GATGCAAACAGCACCTTGGGCCGTACAGTTAGCGGGGTGTAA

Structures

Toxin

• AlphaFold DB: S1PA82

Antitoxin

• AlphaFold DB: U9Z4B8