Detailed information of TA system TA193283

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): chpSB/PRK09812-ChpS
• Location: 3429130..3429725
• Replicon: chromosome
• Accession: NZ_CP070134
• Organism: Escherichia coli strain FDAARGOS_1281

Toxin (Protein)

• Gene name: chpB
• Uniprot ID: V0SXT4
• Locus tag: I6K11_RS17430
• Protein ID: WP_000239581.1
• Coordinates: 3429375..3429725 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: chpS
• Uniprot ID: L4JJX7
• Locus tag: I6K11_RS17425
• Protein ID: WP_001223213.1
• Coordinates: 3429130..3429381 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K11_RS17415 (3424795)	3424795..3428574	+	3780	WP_001522396.1	autotransporter assembly complex protein TamB	-
I6K11_RS17420 (3428577)	3428577..3428918	+	342	WP_001219160.1	gamma-glutamylcyclotransferase	-
I6K11_RS17425 (3429130)	3429130..3429381	+	252	WP_001223213.1	type II toxin-antitoxin system antitoxin ChpS	Antitoxin
I6K11_RS17430 (3429375)	3429375..3429725	+	351	WP_000239581.1	endoribonuclease toxin ChpB	Toxin
I6K11_RS17435 (3429804)	3429804..3430334	-	531	WP_000055075.1	inorganic diphosphatase	-
I6K11_RS17440 (3430644)	3430644..3431600	+	957	WP_001522398.1	galactofuranose ABC transporter substrate-binding protein YtfQ	-
I6K11_RS17445 (3431733)	3431733..3433235	+	1503	WP_001522399.1	sugar ABC transporter ATP-binding protein	-
I6K11_RS17450 (3433249)	3433249..3434271	+	1023	WP_001361374.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (8-114)

Antitoxin

• SpoVT-AbrB domain (6-49)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12453.41 Da
• Isoelectric Point: 6.2206

>T193283 WP_000239581.1 NZ_CP070134:3429375-3429725 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Nucleotide

• Length: 351 bp

>T193283 NZ_CP092830:2038538-2038726 [Pseudomonas azotoformans]
GTGCAAAGCAGGTTATTGATCAAGGAACTGCAAGAGGCAGGTTGGGTGCTGGATCGGGTCACGGGAAGTCATCATATTTT
TACCCATCGCTATAGCCCGTACACCCTTCCAGTGCCCCATCCAAAGAAGGACTTGCCGCTGGGCACCGTCAGAAGCATCA
GGAAACGCGCCGGCTTGTTTCAGTTTTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9331.64 Da
• Isoelectric Point: 4.6509

>AT193283 WP_001223213.1 NZ_CP070134:3429130-3429381 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Nucleotide

• Length: 252 bp

>AT193283 NZ_CP092830:2038738-2039142 [Pseudomonas azotoformans]
ATGCAATACCCAATCTGTATCGAATGGGGCGATGACTTCACTGCCACCGGTATCCAGATCCCCGATATCCCAGGTGCAGT
CACCGCCGGGGACAGTTTTGAAGAGGCGTACAACGCCGCCGTGGAAGTCGCGCACATCATGCTGCAAGAGATCGCCGCAG
AGGGCGGGACGATTCCGATGCCCACGTCGGTCGCCCAGTACCATGCCCACGAGGACTACGCCGGGATGGGCTGGGGTATG
TTGGAACTGGACGTCACGCCCTACCTGGGCAAAACCGAGAAGGTCAATGTGACCCTGCCCGGTTATGTCATCCAGCGCAT
CGACCGCTATGTGCGAGAGCACAAGGTCAAAAGCCGCTCGTCATTCTTGGCGGACGCGGCATTGGAGAAGTTGGTGCGGT
CCTAG

Structures

Toxin

• AlphaFold DB: V0SXT4

Antitoxin

• AlphaFold DB: L4JJX7