193282

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3267433..3268268 Replicon chromosome
Accession NZ_CP070134
Organism Escherichia coli strain FDAARGOS_1281

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0J1YPH7
Locus tag I6K11_RS16560 Protein ID WP_029701676.1
Coordinates 3267433..3267810 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0K5N986
Locus tag I6K11_RS16565 Protein ID WP_021553056.1
Coordinates 3267900..3268268 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K11_RS16540 (3263800) 3263800..3265338 - 1539 WP_001187196.1 lysine decarboxylation/transport transcriptional activator CadC -
I6K11_RS16545 (3266087) 3266087..3266929 - 843 WP_022645115.1 DUF4942 domain-containing protein -
I6K11_RS16550 (3267014) 3267014..3267208 - 195 WP_024181941.1 DUF957 domain-containing protein -
I6K11_RS16555 (3267287) 3267287..3267436 - 150 Protein_3060 DUF5983 family protein -
I6K11_RS16560 (3267433) 3267433..3267810 - 378 WP_029701676.1 TA system toxin CbtA family protein Toxin
I6K11_RS16565 (3267900) 3267900..3268268 - 369 WP_021553056.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
I6K11_RS16570 (3268431) 3268431..3268652 - 222 WP_000692345.1 DUF987 domain-containing protein -
I6K11_RS16575 (3268717) 3268717..3269193 - 477 WP_021553055.1 RadC family protein -
I6K11_RS16580 (3269209) 3269209..3269688 - 480 WP_001564060.1 antirestriction protein -
I6K11_RS16585 (3269954) 3269954..3270772 - 819 WP_001175165.1 DUF932 domain-containing protein -
I6K11_RS16590 (3270862) 3270862..3271095 - 234 WP_001278293.1 DUF905 family protein -
I6K11_RS16595 (3271101) 3271101..3271778 - 678 WP_001097302.1 hypothetical protein -
I6K11_RS16600 (3271926) 3271926..3272606 - 681 WP_029702103.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14066.04 Da        Isoelectric Point: 7.8045

>T193282 WP_029701676.1 NZ_CP070134:c3267810-3267433 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRSNYRTVNNITRGKHPEAKQ

Download         Length: 378 bp

>T193282 NZ_CP092829:537065-537415 [Bacillus pumilus]
TTGATTGTTAAACGCGGTGATGTTTACTTTGCTGATTTATCTCCTGTTGTTGGCTCCGAGCAGGGCGGGGTTCGCCCGGT
ATTGGTGATTCAAAATGACATTGGAAATCGCTTTAGCCCGACTGCTATCGTTGCAGCCATAACAGCCCAAATACAAAAAG
CGAAATTACCGACTCACGTCGAAATTAATGCAAAGCGCTACGGCTTTGAACGAGATTCTGTCATTCTTTTGGAACAGATT
CGTACAATCGATAAACAAAGATTGACAGATAAAATCACACATCTTGATGATGAGATGATGGAGAAGGTTGATGAAGCCTT
ACAAGTTAGTTTGGCTCTTATTGATTTTTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13615.39 Da        Isoelectric Point: 7.0264

>AT193282 WP_021553056.1 NZ_CP070134:c3268268-3267900 [Escherichia coli]
VSDTLSGTTHPDDNHDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGNRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT193282 NZ_CP092829:536779-537060 [Bacillus pumilus]
TTGTCTGAATCCAGCGCAACAAATGAAATGAAGATTCGACTGCCGGAGGCTTTAATGTCTGAGATCGAACGAGTAGCAGA
GCAGGATAAGGTAACAAGAAATGAATTGATCTACCGAGCGACAAAAACGTATATTCGTGAACGTAATATTCGACAAAATC
GTGAATCGATGAGACGCGGCTACATGGAGATGGCGAAAATTAATCTGAATATCTCTTCAGAGGCACAATACGCAGAGTTT
GAGGCTGAGAATACAGTTGAGCGATTAGTCAGCGGGGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1YPH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0K5N986

References