Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 323942..324468 | Replicon | chromosome |
| Accession | NZ_CP070134 | ||
| Organism | Escherichia coli strain FDAARGOS_1281 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | I6K11_RS02640 | Protein ID | WP_000323025.1 |
| Coordinates | 323942..324229 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | I6K11_RS02645 | Protein ID | WP_000534858.1 |
| Coordinates | 324229..324468 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I6K11_RS02595 (319026) | 319026..319484 | - | 459 | WP_000526135.1 | IS200/IS605-like element IS200C family transposase | - |
| I6K11_RS02600 (319935) | 319935..320150 | - | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| I6K11_RS02605 (320451) | 320451..320663 | + | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| I6K11_RS02610 (320718) | 320718..320807 | + | 90 | WP_120795389.1 | hypothetical protein | - |
| I6K11_RS02615 (321085) | 321085..321837 | - | 753 | WP_001047135.1 | antitermination protein | - |
| I6K11_RS02620 (321851) | 321851..322900 | - | 1050 | WP_001265199.1 | DUF968 domain-containing protein | - |
| I6K11_RS02625 (322902) | 322902..323180 | - | 279 | WP_012304870.1 | hypothetical protein | - |
| I6K11_RS02630 (323247) | 323247..323498 | - | 252 | WP_000980994.1 | protein Rem | - |
| I6K11_RS02635 (323715) | 323715..323870 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| I6K11_RS02640 (323942) | 323942..324229 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| I6K11_RS02645 (324229) | 324229..324468 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| I6K11_RS02650 (324493) | 324493..324798 | + | 306 | WP_001326990.1 | protein YdfV | - |
| I6K11_RS02655 (325001) | 325001..325333 | + | 333 | WP_001301033.1 | FlxA-like family protein | - |
| I6K11_RS27560 (325770) | 325770..325919 | - | 150 | WP_011443592.1 | protein YdfW | - |
| I6K11_RS02660 (326040) | 326040..327062 | - | 1023 | Protein_333 | ISNCY family transposase | - |
| I6K11_RS02665 (327567) | 327567..328589 | - | 1023 | WP_000915483.1 | DUF4868 domain-containing protein | - |
| I6K11_RS02670 (328592) | 328592..329206 | - | 615 | WP_001265627.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 291049..353318 | 62269 | |
| - | flank | IS/Tn | - | - | 319026..319484 | 458 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T193264 WP_000323025.1 NZ_CP070134:c324229-323942 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T193264 NZ_CP092825:c2430555-2430289 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGAAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGTTATTATAGTAGACGTATCAATCACGAACATAGATTGGTCTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGAAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGTTATTATAGTAGACGTATCAATCACGAACATAGATTGGTCTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT193264 WP_000534858.1 NZ_CP070134:c324468-324229 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT193264 NZ_CP092825:c2430806-2430555 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACCTCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAATCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGAAAAACTATAACGAAAGAT
ATAGATGTATAA
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACCTCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAATCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGAAAAACTATAACGAAAGAT
ATAGATGTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|