Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/UPF0150(antitoxin) |
| Location | 231091..231729 | Replicon | chromosome |
| Accession | NZ_CP070134 | ||
| Organism | Escherichia coli strain FDAARGOS_1281 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | A0A0D8WF76 |
| Locus tag | I6K11_RS02170 | Protein ID | WP_001306887.1 |
| Coordinates | 231553..231729 (-) | Length | 59 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | - |
| Locus tag | I6K11_RS02165 | Protein ID | WP_001270286.1 |
| Coordinates | 231091..231507 (-) | Length | 139 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I6K11_RS02145 (226243) | 226243..227184 | - | 942 | WP_001251315.1 | ABC transporter permease | - |
| I6K11_RS02150 (227185) | 227185..228198 | - | 1014 | WP_001523231.1 | ABC transporter ATP-binding protein | - |
| I6K11_RS02155 (228216) | 228216..229361 | - | 1146 | WP_020233879.1 | ABC transporter substrate-binding protein | - |
| I6K11_RS02160 (229606) | 229606..231012 | - | 1407 | WP_001523229.1 | PLP-dependent aminotransferase family protein | - |
| I6K11_RS02165 (231091) | 231091..231507 | - | 417 | WP_001270286.1 | type II toxin-antitoxin system antitoxin HicB | Antitoxin |
| I6K11_RS02170 (231553) | 231553..231729 | - | 177 | WP_001306887.1 | type II toxin-antitoxin system mRNA interferase toxin HicA | Toxin |
| I6K11_RS02175 (231951) | 231951..232181 | + | 231 | WP_000494241.1 | YncJ family protein | - |
| I6K11_RS02180 (232273) | 232273..234234 | - | 1962 | WP_024166512.1 | 23S rRNA 5-hydroxycytidine C2501 synthase | - |
| I6K11_RS02185 (234307) | 234307..234843 | - | 537 | WP_020233877.1 | DNA-binding transcriptional regulator SutR | - |
| I6K11_RS02190 (234935) | 234935..236107 | + | 1173 | WP_001523225.1 | BenE family transporter YdcO | - |
| I6K11_RS02195 (236215) | 236215..236673 | - | 459 | WP_000526135.1 | IS200/IS605-like element IS200C family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 236215..236673 | 458 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 59 a.a. Molecular weight: 6768.88 Da Isoelectric Point: 11.5336
>T193263 WP_001306887.1 NZ_CP070134:c231729-231553 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFRGRRSVMPRHPCDEIKEPLRKAILKQLGLS
VKQSEFRRWLESQGVDVANGSNHLKLRFRGRRSVMPRHPCDEIKEPLRKAILKQLGLS
Download Length: 177 bp
>T193263 NZ_CP092825:c2169155-2169051 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA
Antitoxin
Download Length: 139 a.a. Molecular weight: 15246.63 Da Isoelectric Point: 4.7386
>AT193263 WP_001270286.1 NZ_CP070134:c231507-231091 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV
Download Length: 417 bp
>AT193263 NZ_CP092825:2168957-2168995 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|