Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 231091..231729 Replicon chromosome
Accession NZ_CP070134
Organism Escherichia coli strain FDAARGOS_1281

Toxin (Protein)


Gene name hicA Uniprot ID A0A0D8WF76
Locus tag I6K11_RS02170 Protein ID WP_001306887.1
Coordinates 231553..231729 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag I6K11_RS02165 Protein ID WP_001270286.1
Coordinates 231091..231507 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K11_RS02145 (226243) 226243..227184 - 942 WP_001251315.1 ABC transporter permease -
I6K11_RS02150 (227185) 227185..228198 - 1014 WP_001523231.1 ABC transporter ATP-binding protein -
I6K11_RS02155 (228216) 228216..229361 - 1146 WP_020233879.1 ABC transporter substrate-binding protein -
I6K11_RS02160 (229606) 229606..231012 - 1407 WP_001523229.1 PLP-dependent aminotransferase family protein -
I6K11_RS02165 (231091) 231091..231507 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
I6K11_RS02170 (231553) 231553..231729 - 177 WP_001306887.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
I6K11_RS02175 (231951) 231951..232181 + 231 WP_000494241.1 YncJ family protein -
I6K11_RS02180 (232273) 232273..234234 - 1962 WP_024166512.1 23S rRNA 5-hydroxycytidine C2501 synthase -
I6K11_RS02185 (234307) 234307..234843 - 537 WP_020233877.1 DNA-binding transcriptional regulator SutR -
I6K11_RS02190 (234935) 234935..236107 + 1173 WP_001523225.1 BenE family transporter YdcO -
I6K11_RS02195 (236215) 236215..236673 - 459 WP_000526135.1 IS200/IS605-like element IS200C family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 236215..236673 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6768.88 Da        Isoelectric Point: 11.5336

>T193263 WP_001306887.1 NZ_CP070134:c231729-231553 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFRGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T193263 NZ_CP092825:c2169155-2169051 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT193263 WP_001270286.1 NZ_CP070134:c231507-231091 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT193263 NZ_CP092825:2168957-2168995 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D8WF76

Antitoxin

Source ID Structure

References