Detailed information of TA system TA193185

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX(toxin)
• Location: 2680485..2681299
• Replicon: chromosome
• Accession: NZ_CP070111
• Organism: Escherichia coli strain FDAARGOS_1301

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: I6K31_RS12910
• Protein ID: WP_001054376.1
• Coordinates: 2680485..2680742 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: A0A8E0IVE5
• Locus tag: I6K31_RS12915
• Protein ID: WP_001350781.1
• Coordinates: 2680754..2681299 (+)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K31_RS12890 (2675773)	2675773..2676879	+	1107	WP_001309184.1	N-acetylneuraminate epimerase	-
I6K31_RS12895 (2676944)	2676944..2677924	+	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
I6K31_RS25450 (2678034)	2678034..2678239	+	206	Protein_2550	HNH endonuclease	-
I6K31_RS12900 (2678507)	2678507..2679747	-	1241	Protein_2551	helicase YjhR	-
I6K31_RS25455 (2679863)	2679863..2679994	+	132	WP_001309182.1	hypothetical protein	-
I6K31_RS12910 (2680485)	2680485..2680742	+	258	WP_001054376.1	YjhX family toxin	Toxin
I6K31_RS12915 (2680754)	2680754..2681299	+	546	WP_001350781.1	N-acetyltransferase	Antitoxin
I6K31_RS12920 (2681355)	2681355..2682101	+	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
I6K31_RS12925 (2682270)	2682270..2682488	+	219	Protein_2556	hypothetical protein	-
I6K31_RS12930 (2682526)	2682526..2682642	+	117	Protein_2557	VOC family protein	-
I6K31_RS12935 (2682887)	2682887..2684008	+	1122	WP_000010829.1	M42 family metallopeptidase	-
I6K31_RS12940 (2684005)	2684005..2684283	+	279	WP_000722973.1	PTS sugar transporter subunit IIB SgcB	-
I6K31_RS12945 (2684295)	2684295..2685608	+	1314	WP_000460843.1	PTS sugar transporter subunit IIC SgcC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimI / fimA / fimE / fimB	2670270..2689523	19253

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T193185 WP_001054376.1 NZ_CP070111:2680485-2680742 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T193185 NZ_CP092759:1953549-1953651 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19974.91 Da
• Isoelectric Point: 6.3277

>AT193185 WP_001350781.1 NZ_CP070111:2680754-2681299 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFGKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAFIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT193185 NZ_CP092759:c1953658-1953513 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Structures

Toxin

• AlphaFold DB: S1PA82