Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 417827..418658 Replicon chromosome
Accession NZ_CP070111
Organism Escherichia coli strain FDAARGOS_1301

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag I6K31_RS01925 Protein ID WP_000854814.1
Coordinates 417827..418201 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1PWQ3
Locus tag I6K31_RS01930 Protein ID WP_001285586.1
Coordinates 418290..418658 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K31_RS01885 (413223) 413223..414389 + 1167 WP_001297905.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
I6K31_RS01890 (414508) 414508..414981 + 474 WP_001105376.1 DNA gyrase inhibitor SbmC -
I6K31_RS01895 (415179) 415179..416237 + 1059 WP_001200890.1 FUSC family protein -
I6K31_RS01900 (416409) 416409..416738 + 330 WP_000450409.1 DUF496 family protein -
I6K31_RS01905 (416839) 416839..416973 - 135 WP_001297944.1 EutP/PduV family microcompartment system protein -
I6K31_RS01910 (417075) 417075..417221 + 147 Protein_381 transposase domain-containing protein -
I6K31_RS01915 (417510) 417510..417590 - 81 Protein_382 hypothetical protein -
I6K31_RS01920 (417636) 417636..417830 - 195 WP_000988601.1 DUF5983 family protein -
I6K31_RS01925 (417827) 417827..418201 - 375 WP_000854814.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
I6K31_RS01930 (418290) 418290..418658 - 369 WP_001285586.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
I6K31_RS01935 (418732) 418732..418953 - 222 WP_000692323.1 DUF987 domain-containing protein -
I6K31_RS01940 (419022) 419022..419498 - 477 WP_001351157.1 RadC family protein -
I6K31_RS01945 (419514) 419514..419999 - 486 WP_000213703.1 antirestriction protein -
I6K31_RS01950 (420090) 420090..420911 - 822 WP_001234569.1 DUF932 domain-containing protein -
I6K31_RS01955 (421132) 421132..421542 - 411 WP_000846704.1 hypothetical protein -
I6K31_RS01960 (421558) 421558..422235 - 678 WP_001362823.1 hypothetical protein -
I6K31_RS01965 (422371) 422371..423441 - 1071 WP_000102631.1 patatin-like phospholipase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T193158 WP_000854814.1 NZ_CP070111:c418201-417827 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T193158 NZ_CP092739:4200160-4200558 [Leptospira interrogans]
ATGTATCTTTTGGATACCAATATATGCATTTTTCTAATTAAAAAGAAAAATGCGACTCTGTTAGAAAATCTTAAGAAAAA
ATTAAATAAAGATCTATTTGTTTCGTCTTTAACTGTTGCGGAACTTGAGTTTGGAATTCAGAAAAGTGAATTTAAAGAAA
AGAATAAAGTTGCACTAATCGAATTTTTAACGATTTTCAATATACTTTCCTTTTCTGATAAAGATGCAGAGTCTTACGGT
ATCATCAGAGCGGATTTGGAGAGGAAAGGTAATGTAATCGGTTCAATAGACATGTTACTTGCCGCTCAAGCAATTGCTAA
TAATTATATCTTTGTTACTAATAATACAAAAGAATTTAAAAGAATTAAGGCTTTAAAAATAGAAAATTGGACACAATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13563.41 Da        Isoelectric Point: 5.0468

>AT193158 WP_001285586.1 NZ_CP070111:c418658-418290 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT193158 NZ_CP092739:4199930-4200160 [Leptospira interrogans]
ATGCAAACAGCCAAATTATTTATAAATGGAAGAAGTCAAGCGGTCAGATTACCAAAAGAATTTCAATTTACCGGAGATGA
TGTTCTCATTCAAAAAGTCGGAGAGGCGGTAATATTGGTTCCGAAAAACAAGGCCTGGAACGTATTTTTAGAAGGATTGA
ACGGGTTTTCAGATGATTTCTTTAAGGAGGAGAGAGAACAGCCGAAATCTGATAAAAGAGAAAAGCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB S1PWQ3

References