Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2559187..2559703 Replicon chromosome
Accession NZ_CP070105
Organism Klebsiella pneumoniae strain FDAARGOS_1314

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag I6K44_RS12555 Protein ID WP_004178374.1
Coordinates 2559419..2559703 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag I6K44_RS12550 Protein ID WP_002886901.1
Coordinates 2559187..2559429 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K44_RS12535 2555215..2555955 + 741 WP_002886899.1 KDGP aldolase family protein -
I6K44_RS12540 2556022..2557176 + 1155 WP_023159544.1 lactonase family protein -
I6K44_RS12545 2557199..2559109 + 1911 WP_040236557.1 BglG family transcription antiterminator -
I6K44_RS12550 2559187..2559429 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
I6K44_RS12555 2559419..2559703 + 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6K44_RS12560 2559707..2560171 - 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
I6K44_RS12565 2560479..2562617 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
I6K44_RS12570 2562974..2563717 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
I6K44_RS12575 2563720..2563893 - 174 WP_002886906.1 hypothetical protein -
I6K44_RS12580 2563978..2564286 + 309 WP_002886907.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T193151 WP_004178374.1 NZ_CP070105:2559419-2559703 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T193151 NZ_CP092733:c3717485-3716607 [Comamonas thiooxydans]
ATGCACGAGGATTTGCTGTCGCTGAAACAACAGCTGCTGCAGACCGGTTTTCCCGAGCGGCTGGTGAAGCTTCCGCAGAA
GGCCCAGGTCGCCTGGCGCGAGGCTGGCGACGCCAGCTCCGATTTTGCGGTGGTGCTGCTGCATGGCATCAGCTCCGGGG
CTGCATCCTGGCTGGATGTGGCGCTGCAGCTGGGTGACAAGGCGCGCGTTCTGGCCTGGGATGCACCTGGCTATGGCGTG
TCGACGCCGCTGGCCCAATCGGCGCCTGCCGATGCCGACTATGCGCAGGTGCTGGCCCAGTCACTGCTGGTGCTCGGTGT
GCGGCGCTGCATCCTGGTCGGCCATTCCCTGGGCGCCCTGATGGCGGCCAGGCTGGCAGTCACGGCGGCCCCCGGGCTGG
TCGAGCAACTGGTGCTCATCAGCCCGGCGGGCGGCTACGGCGCCCCAGCCAAGGCCGAGCAGCAGGCCAAGGTACGCGAG
GGCCGCCTGGCGGCTCTGGCCGAGAAGGGCGTCGCCGGTCTGGCGGCCGTCATCGATCAGCGCCTGGTGTCCTCCGAGGC
TCCTGAATCCGTGCGTGCATGGGTGCGCTGGAATACGGCGCGCATGCAGCCGCAGGGCTATGCGCAGGCGGTCGAGCTGC
TTTGCGGCAGCGATCTGGCACAGGCACGGGGCAGACTTGGCATGCCGGTCGAGGTTTGGGTCGGCGAGCACGATGTGGTG
ACTACACCTGCAGCTTGCAAGTCCTGGTCCGAACTGCTGGGCGCGCACTACGGTACGCTTGCGGCTGCCGGTCATGCTTC
ACCCGTGGAACAACCAATGGAGGTCGCGCATAGGCTGGCATCTTTGTTGAACCAAAGCTATTGCCCCAATACCAGCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT193151 WP_002886901.1 NZ_CP070105:2559187-2559429 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT193151 NZ_CP092733:c3716601-3715795 [Comamonas thiooxydans]
ATGAGCGAAACCTCCGAGATTTCAACCAACGAACAAGACCGTTACACCGTGCCCGCTCTGGACCGAGGACTGCGCCTGCT
GGCCTGCTTTGGCCCGGCGCAACCGGTCTGGAGCGCACCCGAGCTGGCGCGCAGCCTCGAGCTGCCGCGCTCCACGGTGT
TTCGCATGTTGACCACGCTTGAAAACTCGGGGTATCTGCAGCGCAGCGGCACCGAATACCGGCTCGGTCTGGCCGTGCTG
CGCCTGGGCTATGACTACCTGTCCACCCAGCCGCTGGCGCAACTGGCCGAGCCTGTGCTGCAGGCCTTGTGCGATGAGCT
GGGCATGACCAGCAATCTTGCATTGCGCGACGGCACTTCCGTGGTCTATGTGGCACGCGTCACTCCGTCCGGAGCATTCC
AGGGCGCTGTGCGCGTGGGTTCGCGTCTGCCGGCGCATGCGACGGTGCTGGGACGAGCCCTGTTGCATGACATGGACGGC
GCGCAGCTGCGCTCGGTGTTTGGTGGCGAGGAACTGCCCCAGTTCTCCGAGAGCACGCCGCGCAATATCGACGAGCTGCT
GCGCCTGCTGGCCGAGGATCGCGAGCGTGGCTATGCCATGGGCGAGGGCTTTTACGAGCCTGGCGTTTCGAGTATTGCAG
CGCCGGTGCGCGCCGCAGACGGGCGGGTGGTTGCGGGGTTGGCCATGGCCATTCCGTTTACCGAGCTGGGGCCCGAAAAA
ACCCAGCTCTGGGTGCAGAAGGTGCAGCAGGCGGCAGAGACTCTGTCCGCTCATTTGCGCCAGCAGCACCCGGACCATTT
GCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References