Detailed information of TA system TA193150

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 2394367..2396048
• Replicon: chromosome
• Accession: NZ_CP070105
• Organism: Klebsiella pneumoniae strain FDAARGOS_1314

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A2L0KL13
• Locus tag: I6K44_RS11725
• Protein ID: WP_019704723.1
• Coordinates: 2395131..2396048 (+)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: I6K44_RS11720
• Protein ID: WP_004177809.1
• Coordinates: 2394367..2395125 (+)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K44_RS11705	2390217..2390903	-	687	WP_004151733.1	sel1 repeat family protein	-
I6K44_RS11710	2391133..2393280	-	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
I6K44_RS11715	2393553..2394281	+	729	WP_040181498.1	response regulator transcription factor	-
I6K44_RS11720	2394367..2395125	+	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
I6K44_RS11725	2395131..2396048	+	918	WP_019704723.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
I6K44_RS11730	2396173..2397180	-	1008	WP_004178300.1	carbohydrate kinase family protein	-
I6K44_RS11735	2397255..2398196	-	942	WP_002885156.1	ABC transporter substrate-binding protein	-
I6K44_RS11740	2398227..2399225	-	999	WP_002885172.1	ribose ABC transporter permease	-
I6K44_RS11745	2399222..2400742	-	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34632.07 Da
• Isoelectric Point: 5.4707

>T193150 WP_019704723.1 NZ_CP070105:2395131-2396048 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T193150 NZ_CP092733:c1200216-1199830 [Comamonas thiooxydans]
ATGCCGGTGTCCGTTCTAGTCGATACATCGGTGTGGGTGAGGCATTTTCGTGAGGCAGACACTCACCTGCAGGAATTGCT
TATGCAAGACAGCGTGCTGATGCATTCCATGGTGCATGCAGAGCTGGCCTGTGGCACGCCGCCAGCGCCGCGTGCCGATA
CGCTCGCAGCTCTGGCCATGCTGCGGCCGAGCCAGGAAGCTTCAATTCCCGAGACTTTGGCCTTCCTTGAGAAGAACATG
CTATTCGGTAAGGGCTGCGGCTTGGTCGATCTATCGCTGCTGGCCTCGACGCTAATCACACCAGGCGCTTTGCTTTGGAC
TGCAGATCGACGCCTTGCTGAGTTGGCCGCTCAGCTTGGCGTGGCCTATGCCATACCAACGCATTGA

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT193150 WP_004177809.1 NZ_CP070105:2394367-2395125 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT193150 NZ_CP092733:c1200431-1200216 [Comamonas thiooxydans]
ATGAGATCGACCTTTACGATCGATGACGAAGTCGTAAACCGTGCCCGTGCTGTTGCAGCGCCCGGTATTGCTGTGCCTGA
ACTGGTACGCTTGGCACTTGAAACCTACACGCGTGTCGAGGCAGGCAAGCGCTTGGCTGCCCTGGGCGGAAGCGCGCCAG
ACATGCCTGATGTGCCACGCCGTGGCAGCGCGGCAGATGCTGAAGGCTCTCGCTGA

Structures

Toxin

• AlphaFold DB: A0A2L0KL13

Antitoxin

• AlphaFold DB: A6TH05