Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vagCD/VapC-VagC |
| Location | 18581..19224 | Replicon | plasmid unnamed |
| Accession | NZ_CP070104 | ||
| Organism | Escherichia coli strain FDAARGOS_1277 | ||
Toxin (Protein)
| Gene name | vagD | Uniprot ID | Q84A06 |
| Locus tag | I6K07_RS22700 | Protein ID | WP_000754566.1 |
| Coordinates | 18581..18997 (-) | Length | 139 a.a. |
Antitoxin (Protein)
| Gene name | vagC | Uniprot ID | - |
| Locus tag | I6K07_RS22705 | Protein ID | WP_023300761.1 |
| Coordinates | 18994..19224 (-) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I6K07_RS22675 (I6K07_22675) | 13693..14457 | + | 765 | WP_001389365.1 | IS6-like element IS6100 family transposase | - |
| I6K07_RS22680 (I6K07_22680) | 14950..15534 | - | 585 | WP_001137892.1 | macrolide-binding transcriptional repressor MphR(A) | - |
| I6K07_RS22685 (I6K07_22685) | 15534..16772 | - | 1239 | WP_000004159.1 | macrolide resistance MFS transporter Mrx(A) | - |
| I6K07_RS22690 (I6K07_22690) | 16769..17674 | - | 906 | WP_000219391.1 | Mph(A) family macrolide 2'-phosphotransferase | - |
| I6K07_RS22695 (I6K07_22695) | 17796..18500 | - | 705 | WP_001067834.1 | IS6-like element IS26 family transposase | - |
| I6K07_RS22700 (I6K07_22700) | 18581..18997 | - | 417 | WP_000754566.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| I6K07_RS22705 (I6K07_22705) | 18994..19224 | - | 231 | WP_023300761.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| I6K07_RS22710 (I6K07_22710) | 19834..20127 | + | 294 | WP_020956883.1 | hypothetical protein | - |
| I6K07_RS22715 (I6K07_22715) | 20191..20877 | + | 687 | WP_020956882.1 | hypothetical protein | - |
| I6K07_RS22720 (I6K07_22720) | 20889..21665 | + | 777 | WP_020956881.1 | tyrosine-type recombinase/integrase | - |
| I6K07_RS22725 (I6K07_22725) | 21723..21980 | - | 258 | WP_000764642.1 | hypothetical protein | - |
| I6K07_RS22730 (I6K07_22730) | 22109..22213 | - | 105 | WP_032409716.1 | hypothetical protein | - |
| I6K07_RS22735 (I6K07_22735) | 22743..23609 | + | 867 | WP_004118283.1 | replication initiation protein | - |
| I6K07_RS22740 (I6K07_22740) | 23786..24055 | - | 270 | WP_000339857.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | floR / tet(A) / dfrA1 / qacE / sul1 / mph(A) | - | 1..40637 | 40637 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 15006.52 Da Isoelectric Point: 9.2957
>T193137 WP_000754566.1 NZ_CP070104:c18997-18581 [Escherichia coli]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAVLPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNVREFARVPGLVLEDWVK
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAVLPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNVREFARVPGLVLEDWVK
Download Length: 417 bp
>T193137 NZ_CP092717:741411-741896 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8765.84 Da Isoelectric Point: 4.4189
>AT193137 WP_023300761.1 NZ_CP070104:c19224-18994 [Escherichia coli]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDRIILRPVRPTWGSFAELEKADADFMAEREDVVSDEGRFEP
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDRIILRPVRPTWGSFAELEKADADFMAEREDVVSDEGRFEP
Download Length: 231 bp
>AT193137 NZ_CP092717:741121-741414 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|