Detailed information of TA system TA193101

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 5001047..5001861
• Replicon: chromosome
• Accession: NZ_CP070098
• Organism: Escherichia coli strain FDAARGOS_1370

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: I6L00_RS24560
• Protein ID: WP_001054376.1
• Coordinates: 5001604..5001861 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: U9Z4B8
• Locus tag: I6L00_RS24555
• Protein ID: WP_001309181.1
• Coordinates: 5001047..5001592 (-)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6L00_RS24525 (4996738)	4996738..4998051	-	1314	WP_000460843.1	PTS sugar transporter subunit IIC SgcC	-
I6L00_RS24530 (4998063)	4998063..4998341	-	279	WP_000722973.1	PTS sugar transporter subunit IIB SgcB	-
I6L00_RS24535 (4998338)	4998338..4999459	-	1122	WP_000010829.1	M42 family metallopeptidase	-
I6L00_RS24540 (4999704)	4999704..4999820	-	117	Protein_4703	VOC family protein	-
I6L00_RS24545 (4999858)	4999858..5000076	-	219	Protein_4704	hypothetical protein	-
I6L00_RS24550 (5000245)	5000245..5000991	-	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
I6L00_RS24555 (5001047)	5001047..5001592	-	546	WP_001309181.1	N-acetyltransferase	Antitoxin
I6L00_RS24560 (5001604)	5001604..5001861	-	258	WP_001054376.1	YjhX family toxin	Toxin
I6L00_RS25975 (5002352)	5002352..5002483	-	132	WP_001309182.1	hypothetical protein	-
I6L00_RS24570 (5002599)	5002599..5003839	+	1241	Protein_4709	helicase YjhR	-
I6L00_RS25980 (5004107)	5004107..5004312	-	206	Protein_4710	HNH endonuclease	-
I6L00_RS24575 (5004422)	5004422..5005402	-	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
I6L00_RS24580 (5005467)	5005467..5006573	-	1107	WP_001309184.1	N-acetylneuraminate epimerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T193101 WP_001054376.1 NZ_CP070098:c5001861-5001604 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T193101 NZ_CP092702:c1645633-1645346 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19956.90 Da
• Isoelectric Point: 6.3277

>AT193101 WP_001309181.1 NZ_CP070098:c5001592-5001047 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT193101 NZ_CP092702:c1645872-1645633 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Structures

Toxin

• AlphaFold DB: S1PA82

Antitoxin

• AlphaFold DB: U9Z4B8