Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4733598..4734433 Replicon chromosome
Accession NZ_CP070098
Organism Escherichia coli strain FDAARGOS_1370

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0A1A9A5
Locus tag I6L00_RS23155 Protein ID WP_001564063.1
Coordinates 4733598..4733975 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0A1AEL8
Locus tag I6L00_RS23160 Protein ID WP_038432125.1
Coordinates 4734065..4734433 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L00_RS23135 (4729965) 4729965..4731503 - 1539 WP_001187196.1 lysine decarboxylation/transport transcriptional activator CadC -
I6L00_RS23140 (4732252) 4732252..4733094 - 843 Protein_4422 DUF4942 domain-containing protein -
I6L00_RS23145 (4733179) 4733179..4733373 - 195 WP_024181941.1 DUF957 domain-containing protein -
I6L00_RS23150 (4733452) 4733452..4733601 - 150 Protein_4424 DUF5983 family protein -
I6L00_RS23155 (4733598) 4733598..4733975 - 378 WP_001564063.1 TA system toxin CbtA family protein Toxin
I6L00_RS23160 (4734065) 4734065..4734433 - 369 WP_038432125.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
I6L00_RS23165 (4734596) 4734596..4734817 - 222 WP_000692345.1 DUF987 domain-containing protein -
I6L00_RS23170 (4734882) 4734882..4735358 - 477 WP_021553055.1 RadC family protein -
I6L00_RS23175 (4735374) 4735374..4735853 - 480 WP_001564060.1 antirestriction protein -
I6L00_RS23180 (4735953) 4735953..4736093 + 141 WP_000997937.1 hypothetical protein -
I6L00_RS23185 (4736119) 4736119..4736937 - 819 WP_001175165.1 DUF932 domain-containing protein -
I6L00_RS23190 (4737027) 4737027..4737260 - 234 WP_001278293.1 DUF905 family protein -
I6L00_RS23195 (4737266) 4737266..4737943 - 678 WP_001564058.1 hypothetical protein -
I6L00_RS23200 (4738094) 4738094..4738774 - 681 WP_001278649.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4722477..4768260 45783


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14094.09 Da        Isoelectric Point: 7.8045

>T193098 WP_001564063.1 NZ_CP070098:c4733975-4733598 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRSNYRTVNNITRGKHPEAKQ

Download         Length: 378 bp

>T193098 NZ_CP092702:c1413927-1413733 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13569.31 Da        Isoelectric Point: 7.0369

>AT193098 WP_038432125.1 NZ_CP070098:c4734433-4734065 [Escherichia coli]
VSDTLSGTTHPDDNHDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGNRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT193098 NZ_CP092702:1413556-1413734 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A1A9A5

Antitoxin

Source ID Structure
AlphaFold DB A0A0A1AEL8

References