Detailed information of TA system TA193094

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 3395604..3396438
• Replicon: chromosome
• Accession: NZ_CP070098
• Organism: Escherichia coli strain FDAARGOS_1370

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A8E0IX31
• Locus tag: I6L00_RS16980
• Protein ID: WP_000854689.1
• Coordinates: 3396061..3396438 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: A0A8E0IVP8
• Locus tag: I6L00_RS16975
• Protein ID: WP_001285599.1
• Coordinates: 3395604..3395984 (+)
• Length: 127 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6L00_RS16940 (3391691)	3391691..3392146	+	456	WP_001309747.1	IrmA family protein	-
I6L00_RS16945 (3392289)	3392289..3392378	+	90	WP_225385657.1	DUF905 family protein	-
I6L00_RS16950 (3392557)	3392557..3393378	+	822	WP_001234555.1	DUF932 domain-containing protein	-
I6L00_RS16955 (3393642)	3393642..3394115	+	474	WP_001538139.1	antirestriction protein	-
I6L00_RS16960 (3394131)	3394131..3394607	+	477	WP_001186761.1	RadC family protein	-
I6L00_RS16965 (3394670)	3394670..3394891	+	222	WP_000692315.1	DUF987 domain-containing protein	-
I6L00_RS16970 (3394910)	3394910..3395554	+	645	WP_000086757.1	hypothetical protein	-
I6L00_RS16975 (3395604)	3395604..3395984	+	381	WP_001285599.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
I6L00_RS16980 (3396061)	3396061..3396438	+	378	WP_000854689.1	TA system toxin CbtA family protein	Toxin
I6L00_RS16985 (3396435)	3396435..3396923	+	489	WP_000761698.1	DUF5983 family protein	-
I6L00_RS16990 (3396940)	3396940..3397137	+	198	WP_000839250.1	DUF957 domain-containing protein	-
I6L00_RS16995 (3397222)	3397222..3398067	+	846	WP_001446750.1	DUF4942 domain-containing protein	-
I6L00_RS17000 (3398136)	3398136..3398531	+	396	WP_000208381.1	DUF6088 family protein	-
I6L00_RS17005 (3398524)	3398524..3399457	+	934	Protein_3223	nucleotidyl transferase AbiEii/AbiGii toxin family protein	-
I6L00_RS17010 (3399874)	3399874..3400044	+	171	Protein_3224	IS110 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	3399889..3400044	155

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14042.07 Da
• Isoelectric Point: 9.1510

>T193094 WP_000854689.1 NZ_CP070098:3396061-3396438 [Escherichia coli]
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Nucleotide

• Length: 378 bp

>T193094 NZ_CP092702:c480308-480090 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 127 a.a.
• Molecular weight: 13984.78 Da
• Isoelectric Point: 5.0823

>AT193094 WP_001285599.1 NZ_CP070098:3395604-3395984 [Escherichia coli]
MSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLLQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Nucleotide

• Length: 381 bp

>AT193094 NZ_CP092702:c480708-480334 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG